- December 31: The British Baseball Hall of Fame inducts its 2021 class of Maikel Azcuy, Julian Dodwell, Martyn Dutton and J.G. Lee.
- December 15: Munetaka Murakami wins the 2021 Central League MVP, while Yoshinobu Yamamoto takes home the 2021 Pacific League MVP. Ryoji Kuribayashi wins the CL Rookie of the Year while Hiroya Miyagi is the winner of the PL ROTY.
- December 7: Shingo Takatsu wins the Matsutaro Shoriki Award for 2021.
- December 7: Vladimir Guerrero Jr. is named the winner of the Tip O'Neill Award given out to the outstanding Canadian ballplayer over the past season.
- December 7: Tim Kurkjian wins the BBWAA Career Excellence Award.
- December 5: Six new members are elected to the Hall of Fame by the Veterans Committee: Bud Fowler, Gil Hodges, Jim Kaat, Minnie Minoso, Tony Oliva and Buck O'Neil.
- December 1: The Chinatrust Brothers win the 2021 Taiwan Series. Tzu-Hsien Chan is named Taiwan Series MVP.
- November 29: Ariel Miranda wins the KBO MVP for 2021. Eui-lee Lee wins KBO Rookie of the Year.
- November 27: The Yakult Swallows win the 2021 Japan Series for their first title in 20 years. Yuhei Nakamura is named Series MVP.
- November 22: Buster Posey and Trey Mancini win Comeback Player of the Year.
- November 22: Yoshinobu Yamamoto wins the Sawamura Award for 2021.
- November 18: Shohei Ohtani wins the MVP Award in the American League and Bryce Harper in the National League.
- November 18: The kt Wiz win the 2021 Korean Series for their first Korean Series title. Kyung-su Park is named Korean Series MVP.
- November 17: Winners of the Cy Young Award are announced: Robbie Ray in the American League and Corbin Burnes in the National League.
- November 16: Gabe Kapler and Kevin Cash win Manager of the Year in the NL and AL, respectively.
- November 15: Randy Arozarena is voted as the Rookie of the Year in the American League and Jonathan India wins the Award in the National League.
- November 10: Liam Hendriks wins the Mariano Rivera Award while Josh Hader wins the Trevor Hoffman Award.
- November 2: The Atlanta Braves win the 2021 World Series over the Houston Astros; Jorge Soler is named World Series MVP.
- October 24: The Rouen Huskies win the French Division I championship.
- October 24: The Hoboken Pioneers win the First Division title for the first time in 9 years.
- October 23: The Atlanta Braves are the National League champions for the first time since 1999 after defeating the Los Angeles Dodgers in the National League Championship Series. Eddie Rosario is named NLCS MVP.
- October 22: The Houston Astros win the American League pennant by defeating the Boston Red Sox in the American League Championship Series; Yordan Alvarez is the ALCS MVP.
- October 17: The Amsterdam Pirates win the 2021 Holland Series. Sharlon Schoop is named Series MVP.
- October 13: The Canadian Baseball Hall of Fame announces a large class of inductees, all of them Canadian baseball pioneers: Bob Addy, James F. Cairns, Helen Callaghan, Jimmy Claxton, Charlie Culver, William Galloway, Roland Gladu, Vern Handrahan, Manny McIntyre, Joe Page, Ernie Quigley, Hector Racine, Jimmy Rattlesnake, Jean-Pierre Roy, Fred Thomas, Roy Yamamura and the 1877 London Tecumsehs.
- October 9: Denzel Richardson wins 2021 Hoofdklasse MVP.
- September 19: The Dutch national team wins the 2021 European Championship. Roger Bernadina is named European Championship MVP.
- September 15: The Toros de Tijuana win the Mexican League title, defeating Leones de Yucatan in seven games after losing the first three in the Serie del Rey. Efrén Navarro is named finals MVP.
- September 12: Max Scherzer becomes the 19th pitcher with 3,000 strikeouts.
- September 11: Corbin Burnes and Josh Hader combine to throw the 9th no-hitter of the season, breaking the record for most in a single year.
- August 30: The team from Taylor, MI defeats Hamilton, OH in the final game to win the 2021 Little League World Series.
- August 30: Heidenheim Heideköpfe wins their third straight Bundesliga championship. 46-year-old Enorbel Márquez takes the finals MVP.
- August 29: The Leksand Lumberjacks win their 23rd Elitserien title. Per Sjörs is finals MVP.
- August 22: Miguel Cabrera becomes the 28th member of the 500 Home Run Club.
- August 20: The Arrows Ostrava win the Extraliga title for the third time in four years.
- August 18: ASD San Marino wins the 2021 Italian Series. Tiago Da Silva wins Series MVP.
- August 15: The Tenerife Marlins win the Spanish Baseball League title for the 7th time in 9 years.
- August 14: In his first major league start, Tyler Gilbert of the Diamondbacks pitches the 8th no-hitter of the season, matching the all-time record set in 1884.
- August 7: Japan wins the Gold Medal at the 2020 Tokyo Olympics by defeating the USA, 2-0, in the Gold Medal Game. The Dominican Republic takes Bronze. Tetsuto Yamada is named Olympic MVP.
- July 17: Parma wins the 2021 European Cup, their 14th European Cup but first this century. Alex Sambucci is named Cup MVP.
- July 13: The American League wins the All-Star Game, 5-2. Vladimir Guerrero Jr. receives the Ted Williams Award as the game's MVP.
- July 12: Pete Alonso successfully defends his title by winning the Home Run Derby.
- July 11: Catcher Henry Davis of the University of Louisville is the first overall pick in the 2021 Amateur Draft.
- July 11: The National League wins the 2021 Futures Game, 8-3, over the American League. Brennen Davis is named recipient of the Larry Doby Award as the game's MVP.
- June 30: Mississippi State University wins the 2021 College World Series, defeating Vanderbilt University, 9-0, in the final game. Sophomore P Will Bednar is named the College World Series Most Outstanding Player.
- June 26: The Dominican Republic wins the Final Olympic Qualifier.
- June 24: Four Chicago Cubs pitchers - Zach Davies, Ryan Tepera, Andrew Chafin and Craig Kimbrel - combine to pitch the 7th no-hitter of the season, one shy of the all-time record.
- June 12: Wingate University wins the 2021 Division II College World Series.
- June 9: Salisbury University wins the 2021 Division III College World Series for their first title.
- June 5: Team USA wins the Americas Olympic Qualifier.
- May 31: Andrew Albers and two Team Canada relievers no-hit the Colombian national team in the 2021 Americas Olympic Qualifier.
- May 29: Josh Donaldson scores the 2,000,000th run in major league history.
- May 25: Joe West sets a new record by working his 5,376th game as a major league umpire, passing Bill Klem.
- May 19: One day after Spencer Turnbull's feat, Corey Kluber of the Yankees keeps up the record pace of no-hitters this season, pitching one over the Rangers, 2-0.
- May 18: Spencer Turnbull of the Detroit Tigers pitches what is already the 5th nine-inning no-hitter of the season, shutting out the Mariners, 5-0.
- May 7: The parade of no-hitters continues with Wade Miley of the Reds pitching one against the Indians.
- May 5: John Means of the Orioles pitches the third official no-hitter of the season, 6-0 over the Mariners.
- April 25: Madison Bumgarner pitches a seven-inning no-hitter in the second game of a doubleheader.
- April 14: Carlos Rodon of the White Sox pitches a no-hitter, defeating the Indians, 8-0.
- April 9: Joe Musgrove pitches the first no-hitter of the season and the first in the history of the San Diego Padres.
- April 4: The Alazanes de Granma win the 2020-2021 Cuban Serie Nacional.
- April 1: Tokai University Sagami High School wins the 2021 spring Koshien.
- March 25: Lisbán Correa wins Serie Nacional MVP for 2020-2021, the first former defector to win. Marlon Vega wins Rookie of the Year.
- March 11: Darryl George wins the Helms Award for the 2020-2021 Australian Baseball League.
- February 11: The Melbourne Aces win the 2020-2021 Australian Baseball League. Tyler Beardsley wins the championship game MVP.
- February 6: The Águilas Cibaeñas win the 2021 Caribbean Series. Juan Lagares is named Caribbean Series MVP.
- January 30: Darryl George sets Australian Baseball League records for RBI (10) and grand slams (2) in a game.
- January 30: The Tomateros de Culiacán repeat as Mexican Pacific League champs.
- January 26: The Caribes de Anzoátegui win their 4th Venezuelan League title.
- January 26: The 2021 Hall of Fame Election ends with no players being selected.
- January 24: The Criollos de Caguas win their record 19th Puerto Rican League title.
- January 22: Hank Aaron, whose breaking of Babe Ruth's record of 714 career homers was one of the most iconic moments of the 1970s, dies at age 86.
- January 21: Sebastián Elizalde wins Mexican Pacific League MVP.
- January 19: Pitcher Don Sutton, a Hall of Famer and the winner of 324 games, passes away at age 75.
- January 18: The Águilas Cibaeñas win their 22nd Dominican League title to tie for the record.
- January 14: Katsuji Kawashima and Kazuo Sayama win induction in the 2021 Japanese Baseball Hall of Fame Election.
- January 7: Tommy Lasorda, the oldest living Hall of Famer, dies at 93.
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