- December 23: Vladimir Baños throws a no-hit, no-walk gem and only one error denies him a perfect game.
- December 15: Hall of Famer Bob Feller dies at age 92.
- December 9: Bill Conlin is honored with the J. G. Taylor Spink Award.
- December 9: Josh Rodriguez is the first pick in the Rule V Draft.
- December 8: Alfredo Meli is named to the Italian Baseball Hall of Fame. Also, Orlando Muñoz is honored as the Italian Baseball League MVP for 2010.
- December 8: Dave Van Horne wins the Ford Frick Award.
- December 6: Pat Gillick is voted into the Hall of Fame by the Veterans Committee.
- November 23: Josh Hamilton wins the 2010 American League MVP.
- November 22: Joey Votto is named NL MVP for 2010.
- November 19: The South Korean national team wins Gold at the 2010 Asian Games.
- November 18: Felix Hernandez wins the 2010 American League Cy Young Award
- November 18: Kazuhiro Wada and Tsuyoshi Wada are named Central League and Pacific League MVPs, respectively, for 2010.
- November 17: Bud Black and Ron Gardenhire win Manager of the Year for 2010.
- November 16: Roy Halladay wins the 2010 National League Cy Young Award.
- November 15: Norifumi Nishimura wins the Matsutaro Shoriki Award.
- November 15: Buster Posey and Neftali Feliz win Rookie of the Year honors.
- November 7: The Chiba Lotte Marines win the 2010 Japan Series. Toshiaki Imae is named Japan Series MVP.
- November 7: Cheng-Min Peng wins the CPBL MVP for 2010.
- November 4: Hall of Fame manager Sparky Anderson dies.
- November 1: The San Francisco Giants win the 2010 World Series in five games. Edgar Renteria is named the World Series MVP.
- November 1: Kenta Maeda wins the 2010 Sawamura Award.
- October 31: Cuba wins the 2010 Intercontinental Cup, topping the Netherlands in the finale. Héctor Olivera Jr. is named MVP. Italy wins Bronze, its first medal in a global event.
- October 31: Jose Bautista and Joey Votto win the Hank Aaron Award.
- October 27: Dalier Hinojosa' throws his second perfect game this year in international competition, against Hong Kong at the 2010 Intercontinental Cup.
- October 25 Dae-ho Lee is named KBO MVP for 2010. Eui-ji Yang wins Rookie of the Year.
- October 23: The Brother Elephants win the 2010 Taiwan Series. Jim Magrane is named Taiwan Series MVP.
- October 19: The SK Wyverns win the 2010 Korean Series. Jung-kwon Park is named Korean Series MVP.
- October 17: Draci Brno wins their 16th straight Extraliga championship, 3 games to 2 over Technika Brno.
- October 10: The Latin American Baseball Hall of Fame announces a class of 11 honorees, including Luis Tiant, Dennis Martinez, Edgar Martinez and Fernando Valenzuela.
- October 9: The Regensburg Legionäre win their second Bundesliga title. Klaus Hopfensperger is MVP of the finals.
- October 6: Roy Halladay throws the second no-hitter in postseason history. It is the first since Don Larsen's perfect game in the 1956 World Series.
- October 5: Matt Murton breaks Ichiro Suzuki's record for hits in a season in Nippon Pro Baseball.
- October 2: The Hoboken Pioneers win the Belgian Series for their second title in a row.
- September 26: Dae-ho Lee wins the third Triple Crown in the 29 years of the Korea Baseball Organization; he becomes the first multiple winner, having turned the feat in 2006.
- September 26: Norichika Aoki becomes the first Nippon Pro Baseball player with multiple 200-hit seasons.
- September 26: Fortitudo Bologna wins the 2010 European Cup. Heidenheim Heideköpfe becomes the first Bundesliga team to win a Medal at a European Cup, taking Silver.
- September 24: Aroldis Chapman becomes the first pitcher timed at 105 mph in a MLB game.
- September 23: Matt Murton tops 200 hits, the first American to do so in Nippon Pro Baseball.
- September 21: The Columbus Clippers win the 2010 Triple-A National Championship. Jerad Head is named MVP.
- September 17: DOOR Neptunus wins the 2010 Holland Series. Dushan Ruzic wins MVP honors.
- September 11: Cariparma Parma wins the 2010 Italian Series. Marcos Yepez is named MVP.
- September 7: Trevor Hoffman becomes the first pitcher with 600 saves.
- September 5: Bill Lee wins an independent league game at age 63, a record.
- August 29: Tokyo wins the 2010 Little League World Series.
- August 26: Alex Ramirez sets a Nippon Pro Baseball record with 100 RBI eight straight seasons, breaking Sadaharu Oh's 41-year-old record.
- August 26: Yoshinori Sato becomes the first Japanese pitcher to hit 100 mph on the radar gun.
- August 22: Japan wins the 2010 Women's Baseball World Cup. Ayako Rokkaku is named MVP.
- August 22: Matt Stairs hits his record 21st career pinch-hit homer, breaking Cliff Johnson's mark.
- August 21: Kounan High School wins the 2010 summer Koshien.
- August 18: Cheng-Min Peng becomes the fastest player in CPBL history to 1,000 hits.
- August 16: The Saraperos de Saltillo win the 2010 Mexican League title.
- August 14: Dae-ho Lee of the Lotte Giants homers in 9 straight games to set a Korea Baseball Organization record.
- August 7: Cuba wins the 2010 World University Championship. Alfredo Despaigne is named MVP.
- August 4: Alex Rodriguez hits the 600th home run of his career, becoming the 7th - and youngest - player to reach the mark in Major League Baseball history.
- August 1: Taiwan wins the 2010 World Junior Championship, their first Gold in the event in 27 years. Australia has its best finish ever, getting the Silver.
- August 1: The Italian national team wins the 2010 European Championship, their first European Championship title in 13 years. Giuseppe Mazzanti is named MVP.
- July 28: The Dominican national team wins the 2010 Central American and Caribbean Games, their first tournament Gold Medal in 28 years.
- July 26: Matt Garza pitches the first no-hitter in the history of the Tampa Bay Rays, blanking Detroit 5-0 for the major leagues' 5th no-hitter of the season.
- July 24: Rob Cordemans and Dave Draijer of the Netherlands no-hit France at the 2010 European Championship.
- July 24: The Central League takes the 2010 NPB All-Star Games by a 1-0-1 margin. Shinnosuke Abe was game one MVP and Yasuyuki Kataoka game two MVP.
- July 22: Tai-Shan Chang becomes the first player in CPBL history to 1,000 RBI.
- July 13: The National League wins the 2010 All-Star Game by a 3-1 margin, ending a 13-game drought. Brian McCann is named MVP.
- July 13: Bryce Harper wins the Golden Spikes Award, the first junior college player so honored in 20 years.
- July 13: New York Yankees owner George Steinbrenner passes away, two days after long-time public address announcer Bob Sheppard.
- July 11: The United States wins the 2010 Futures Game. Hank Conger wins the Larry Doby Award as MVP.
- July 10: CB Sant Boi wins the 2010 Division Honor pennant.
- July 4: Harold Garcia sets a new Florida State League record with a 37-game hitting streak, topping the 59-year-old mark.
- June 29: The University of South Carolina wins the 2010 College World Series for their first national title. Jackie Bradley Jr. is named the College World Series Most Outstanding Player.
- June 27: Jamie Moyer breaks Robin Roberts' decades-old record for homers allowed in the majors.
- June 25: Edwin Jackson of the Arizona Diamondbacks throws the 4th no-hitter of the season, blanking his former team, the Tampa Bay Rays.
- June 22: DOOR Neptunus breaks a 21-year-old Hoofdklasse record by winning 19 straight.
- June 22: Dovydas Neverauskas becomes the first Lithuanian to play in Organized Baseball.
- June 7: Bryce Harper is the first pick of the 2010 amateur draft.
- June 3: Cumberland University wins the 2010 NAIA College World Series.
- June 2: Ken Griffey Jr. retires after 22 seasons in the majors, ending his career with 630 home runs.
- June 1: Illinois Wesleyan University wins the 2010 Division III College World Series. Their 21 losses are the most ever by a college national champion.
- May 29: Roy Halladay of the Philadelphia Phillies pitches a perfect game against the Florida Marlins. The game comes only 20 days after Dallas Braden's similar gem, making it the first time since 1880 that two perfect games are thrown in the same season.
- May 29: The University of Southern Indiana wins the 2010 Division II College World Series for their first national title.
- May 11: Hyun-jin Ryu of the Hanwha Eagles set a Korea Baseball Organization record with 17 strikeouts in a nine-inning game.
- May 9: Dallas Braden of the Oakland Athletics throws a perfect game against the Tampa Bay Rays.
- May 7: Jamie Moyer becomes the oldest pitcher to throw a shutout in the major leagues and the first to do so in four different decades.
- May 7: Starlin Castro sets a modern record for RBI in a major league debut with six. He also becomes the first major leaguer born in the 1990s.
- May 6: Hall of Fame pitcher Robin Roberts passes away, a day after Japanese Baseball Hall of Famer Kenjiro Tamiya.
- May 4: Legendary announcer Ernie Harwell dies.
- April 26: Alfredo Despaigne is named MVP of the 2009-2010 Serie Nacional.
- April 18: Tomoaki Kanemoto ends his pro baseball world record of 1,492 consecutive games playing every inning.
- April 17: Ubaldo Jimenez pitches the first no-hitter in the history of the Colorado Rockies, blanking the Atlanta Braves, 4-0.
- April 11: Mike Leake becomes the first drafted player to go straight to the majors in 10 years.
- April 11: Zsolt Zabalai throws the first no-hitter in Hungarian baseball history.
- April 7: 37-year-old Yomiuri Giants coach Takuya Kimura dies of a brain hemorrhage suffered four days ago.
- April 4: The Boston Red Sox defeat the their traditional rivals, the New York Yankees, 9 - 7, on Opening Day for Major League Baseball.
- April 2: Jim Brower throws a no-hitter in his Italian Baseball League debut.
- March 31: The Industriales win the 2009-2010 Serie Nacional.
- March 27: The Venezuelan national team takes Gold at the 2010 South American Games despite not registering a team until shortly before the Games began.
- March 1: The first Henry Chadwick Awards are given out by SABR.
- February 7: The Leones del Escogido win the 2010 Caribbean Series with a 5-1 record in the tournament. Fernando Martinez is named Series MVP.
- February 6: The Victoria Aces win the 2010 Claxton Shield. Matthew Blackmore is named Finals MVP.
- February 3: Wilson Álvarez and Oscar Azócar are inducted into the Caribbean Baseball Hall of Fame.
- February 1: Jon Miller wins the Ford Frick Award.
- January 30: The Naranjeros de Hermosillo are the 2009-2010 champions of the Mexican Pacific League.
- January 29: The Leones del Caracas take the Venezuelan League pennant.
- January 29: The Indios de Mayagüez claim the Puerto Rican League title for 2009-2010.
- January 28: The Leones del Escogido win the 2009-2010 Dominican League title.
- January 28: Paul Quantrill, Allan Roth, Roberto Alomar and Calvin Griffith are voted into the Canadian Baseball Hall of Fame.
- January 23: A group headed by Hall of Fame pitcher Nolan Ryan and attorney Chuck Greenberg purchase the Texas Rangers from Tom Hicks for a price said to exceed $500 million.
- January 12: Shinichi Eto, Osamu Higashio and Masayuki Furuta are voted into the Japanese Baseball Hall of Fame.
- January 9: The 2009 Hoofdklasse awards are announced. Ryan Murphy is named MVP and Pitcher of the Year while Steve Janssen is named Coach of the Year.
- January 6: Andre Dawson is elected to the Hall of Fame by the BBWAA. Over a 21-year career, "The Hawk" won an MVP Award and hit .279 with 438 home runs, 1,591 RBI and 314 steals.
- January 5: 300 game winner Randy Johnson announces his retirement after 22 seasons. The 6'10" left-hander struck out 4,875 batters in his career, the second highest total in history.
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