Inland Empire 66ers
- Location: San Bernardino, CA
- League: California League 2003-2019; Low-A West 2021-
- Affiliation: Seattle Mariners 2003-2006; Los Angeles Dodgers 2007-2010; Los Angeles Angels 2011-present
- Ballpark: San Manuel Stadium
The Inland Empire 66ers are the California League affiliate of the Los Angeles Angels. They play their home games at Arrowhead Credit Union Park in San Bernardino, CA. The 66ers were league champs in 2003 and captured the title again in 2006.