Single-Season Leaders & Records for Strikeouts
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| Rank | Player (age that year) | Strikeouts | Year | Throws |
|---|---|---|---|---|
| 1. | Matt Kilroy (20) | 513 | 1886 | L |
| 2. | Toad Ramsey (21) | 499 | 1886 | L |
| 3. | Hugh Daily (36) | 483 | 1884 | R |
| 4. | Dupee Shaw (25) | 451 | 1884 | L |
| 5. | Old Hoss Radbourn+ (29) | 441 | 1884 | R |
| 6. | Charlie Buffinton (23) | 417 | 1884 | R |
| 7. | Guy Hecker (28) | 385 | 1884 | R |
| 8. | Nolan Ryan+ (26) | 383 | 1973 | R |
| 9. | Sandy Koufax+ (29) | 382 | 1965 | L |
| 10. | Bill Sweeney (26) | 374 | 1884 | R |
| 11. | Randy Johnson+ (37) | 372 | 2001 | L |
| 12. | Pud Galvin+ (27) | 369 | 1884 | R |
| 13. | Mark Baldwin (25) | 368 | 1889 | R |
| 14. | Nolan Ryan+ (27) | 367 | 1974 | R |
| 15. | Randy Johnson+ (35) | 364 | 1999 | L |
| 16. | Tim Keefe+ (26) | 359 | 1883 | R |
| 17. | Toad Ramsey (22) | 355 | 1887 | L |
| 18. | Rube Waddell+ (27) | 349 | 1904 | L |
| 19. | Bob Feller+ (27) | 348 | 1946 | R |
| 20. | Randy Johnson+ (36) | 347 | 2000 | L |
| 21. | Hardie Henderson (21) | 346 | 1884 | R |
| 22. | Mickey Welch+ (24) | 345 | 1884 | R |
| Jim Whitney (25) | 345 | 1883 | R | |
| 24. | Jim McCormick (27) | 343 | 1884 | R |
| 25. | Amos Rusie+ (19) | 341 | 1890 | R |
| Nolan Ryan+ (30) | 341 | 1977 | R | |
| 27. | Amos Rusie+ (20) | 337 | 1891 | R |
| Charlie Sweeney (21) | 337 | 1884 | R | |
| 29. | Tim Keefe+ (31) | 335 | 1888 | R |
| 30. | Randy Johnson+ (38) | 334 | 2002 | L |
| Tim Keefe+ (27) | 334 | 1884 | R | |
| 32. | Randy Johnson+ (34) | 329 | 1998 | L |
| Nolan Ryan+ (25) | 329 | 1972 | R | |
| 34. | Nolan Ryan+ (29) | 327 | 1976 | R |
| 35. | Gerrit Cole (28) | 326 | 2019 | R |
| Ed Morris (23) | 326 | 1886 | L | |
| 37. | Sam McDowell (22) | 325 | 1965 | L |
| Tony Mullane (25) | 325 | 1884 | R | |
| 39. | Lady Baldwin (27) | 323 | 1886 | L |
| 40. | Curt Schilling (30) | 319 | 1997 | R |
| 41. | Sandy Koufax+ (30) | 317 | 1966 | L |
| 42. | Curt Schilling (35) | 316 | 2002 | R |
| 43. | Old Hoss Radbourn+ (28) | 315 | 1883 | R |
| 44. | Bill Hutchison (32) | 314 | 1892 | R |
| 45. | John Clarkson+ (24) | 313 | 1886 | R |
| Walter Johnson+ (22) | 313 | 1910 | R | |
| Pedro Martinez+ (27) | 313 | 1999 | R | |
| J.R. Richard (29) | 313 | 1979 | R | |
| 49. | Steve Carlton+ (27) | 310 | 1972 | L |
| 50. | John Clarkson+ (23) | 308 | 1885 | R |
| Rank | Player (age that year) | Strikeouts | Year | Throws |
| Randy Johnson+ (29) | 308 | 1993 | L | |
| Mickey Lolich (30) | 308 | 1971 | L | |
| Larry McKeon (18) | 308 | 1884 | ||
| Chris Sale (28) | 308 | 2017 | L | |
| 55. | Sandy Koufax+ (27) | 306 | 1963 | L |
| Mike Scott (31) | 306 | 1986 | R | |
| 57. | Pedro Martinez+ (25) | 305 | 1997 | R |
| 58. | Sam McDowell (27) | 304 | 1970 | L |
| Amos Rusie+ (21) | 304 | 1892 | R | |
| 60. | Walter Johnson+ (24) | 303 | 1912 | R |
| J.R. Richard (28) | 303 | 1978 | R | |
| 62. | Ed Morris (21) | 302 | 1884 | L |
| Rube Waddell+ (26) | 302 | 1903 | L | |
| 64. | Vida Blue (21) | 301 | 1971 | L |
| Clayton Kershaw (27) | 301 | 2015 | L | |
| Nolan Ryan+ (42) | 301 | 1989 | R | |
| 67. | Max Scherzer (33) | 300 | 2018 | R |
| Curt Schilling (31) | 300 | 1998 | R | |
| Justin Verlander (36) | 300 | 2019 | R | |
| 70. | Ed Morris (22) | 298 | 1885 | L |
| 71. | Tim Keefe+ (29) | 297 | 1886 | R |
| 72. | Randy Johnson+ (31) | 294 | 1995 | L |
| 73. | Curt Schilling (34) | 293 | 2001 | R |
| 74. | Roger Clemens (34) | 292 | 1997 | R |
| Jack Lynch (27) | 292 | 1884 | R | |
| 76. | Roger Clemens (25) | 291 | 1988 | R |
| Randy Johnson+ (33) | 291 | 1997 | L | |
| Sadie McMahon (22) | 291 | 1890 | R | |
| 79. | Randy Johnson+ (40) | 290 | 2004 | L |
| Justin Verlander (35) | 290 | 2018 | R | |
| 81. | Bill Hutchison (30) | 289 | 1890 | R |
| Tom Seaver+ (26) | 289 | 1971 | R | |
| Jack Stivetts (22) | 289 | 1890 | R | |
| 84. | Rube Waddell+ (28) | 287 | 1905 | L |
| 85. | Steve Carlton+ (35) | 286 | 1980 | L |
| Steve Carlton+ (37) | 286 | 1982 | L | |
| Bobby Mathews (32) | 286 | 1884 | R | |
| Bobby Mathews (33) | 286 | 1885 | R | |
| 89. | John Clarkson+ (27) | 284 | 1889 | R |
| Pedro Martinez+ (28) | 284 | 2000 | R | |
| Max Scherzer (31) | 284 | 2016 | R | |
| Billy Taylor (29) | 284 | 1884 | R | |
| 93. | Dave Foutz (29) | 283 | 1886 | R |
| Sam McDowell (25) | 283 | 1968 | L | |
| Tom Seaver+ (25) | 283 | 1970 | R | |
| 96. | Denny McLain (24) | 280 | 1968 | R |
| 97. | Pud Galvin+ (26) | 279 | 1883 | R |
| Sam McDowell (26) | 279 | 1969 | L | |
| 99. | Yu Darvish (26) | 277 | 2013 | R |
| 100. | Gerrit Cole (27) | 276 | 2018 | R |
| Rank | Player (age that year) | Strikeouts | Year | Throws |
| Dwight Gooden (19) | 276 | 1984 | R | |
| Max Scherzer (30) | 276 | 2015 | R | |
| John Smoltz+ (29) | 276 | 1996 | R | |
| Bob Veale (29) | 276 | 1965 | L | |
| 105. | Steve Carlton+ (38) | 275 | 1983 | L |
| Hal Newhouser+ (25) | 275 | 1946 | L | |
| 107. | Bob Gibson+ (34) | 274 | 1970 | R |
| Fergie Jenkins+ (27) | 274 | 1970 | R | |
| Chris Sale (26) | 274 | 2015 | L | |
| Mario Soto (25) | 274 | 1982 | R | |
| 111. | Fergie Jenkins+ (26) | 273 | 1969 | R |
| 112. | Larry Corcoran (24) | 272 | 1884 | R |
| Ed Seward (21) | 272 | 1888 | R | |
| Mickey Welch+ (26) | 272 | 1886 | R | |
| 115. | Roger Clemens (35) | 271 | 1998 | R |
| Mickey Lolich (28) | 271 | 1969 | L | |
| David Price (28) | 271 | 2014 | L | |
| 118. | Bob Gibson+ (29) | 270 | 1965 | R |
| Nolan Ryan+ (40) | 270 | 1987 | R | |
| Jim Whitney (26) | 270 | 1884 | R | |
| 121. | Jacob deGrom (30) | 269 | 2018 | R |
| Bob Gibson+ (33) | 269 | 1969 | R | |
| Corey Kluber (28) | 269 | 2014 | R | |
| Sandy Koufax+ (25) | 269 | 1961 | L | |
| Frank Tanana (21) | 269 | 1975 | L | |
| Justin Verlander (26) | 269 | 2009 | R | |
| Ed Walsh+ (27) | 269 | 1908 | R | |
| 128. | Jim Bunning+ (33) | 268 | 1965 | R |
| Larry Corcoran (20) | 268 | 1880 | R | |
| Bob Gibson+ (32) | 268 | 1968 | R | |
| Dwight Gooden (20) | 268 | 1985 | R | |
| Max Scherzer (32) | 268 | 2017 | R | |
| Bill Wise (23) | 268 | 1884 | ||
| 134. | Christy Mathewson+ (22) | 267 | 1903 | R |
| 135. | Kerry Wood (26) | 266 | 2003 | R |
| 136. | Corey Kluber (31) | 265 | 2017 | R |
| Tim Lincecum (24) | 265 | 2008 | R | |
| Jim Maloney (23) | 265 | 1963 | R | |
| Johan Santana (25) | 265 | 2004 | L | |
| 140. | Bob Emslie (25) | 264 | 1884 | R |
| Ben Sheets (25) | 264 | 2004 | R | |
| Luis Tiant (27) | 264 | 1968 | R | |
| 143. | Hardie Henderson (22) | 263 | 1885 | R |
| Fergie Jenkins+ (28) | 263 | 1971 | R | |
| Herb Score (23) | 263 | 1956 | L | |
| 146. | Mark Langston (26) | 262 | 1987 | L |
| Phil Niekro+ (38) | 262 | 1977 | R | |
| Dazzy Vance+ (33) | 262 | 1924 | R | |
| 149. | David Cone (29) | 261 | 1992 | R |
| Bob Feller+ (21) | 261 | 1940 | R | |
| Rank | Player (age that year) | Strikeouts | Year | Throws |
| Bill Hutchison (31) | 261 | 1891 | R | |
| Tim Lincecum (25) | 261 | 2009 | R | |
| Frank Tanana (22) | 261 | 1976 | L | |
| 154. | Bob Feller+ (22) | 260 | 1941 | R |
| Fergie Jenkins+ (25) | 260 | 1968 | R | |
| Jim McCormick (23) | 260 | 1880 | R | |
| Nolan Ryan+ (31) | 260 | 1978 | R | |
| 158. | Shane Bieber (24) | 259 | 2019 | R |
| Christy Mathewson+ (27) | 259 | 1908 | R | |
| Jack Stivetts (23) | 259 | 1891 | R | |
| 161. | Bert Blyleven+ (22) | 258 | 1973 | R |
| Silver King (20) | 258 | 1888 | R | |
| Ed Walsh+ (29) | 258 | 1910 | R | |
| Mickey Welch+ (25) | 258 | 1885 | R | |
| Smoky Joe Wood (22) | 258 | 1912 | R | |
| 166. | Kevin Brown (33) | 257 | 1998 | R |
| Roger Clemens (33) | 257 | 1996 | R | |
| Toad Ramsey (25) | 257 | 1890 | L | |
| 169. | Roger Clemens (24) | 256 | 1987 | R |
| 170. | James Burke | 255 | 1884 | |
| Jacob deGrom (31) | 255 | 2019 | R | |
| Ed Walsh+ (30) | 255 | 1911 | R | |
| 173. | Justin Verlander (33) | 254 | 2016 | R |
| Ed Walsh+ (31) | 254 | 1912 | R | |
| 175. | Trevor Bauer (28) | 253 | 2019 | R |
| Jim Bunning+ (35) | 253 | 1967 | R | |
| Jose Fernandez (23) | 253 | 2016 | R | |
| 178. | Chris Archer (26) | 252 | 2015 | R |
| Jim Bunning+ (34) | 252 | 1966 | R | |
| Max Scherzer (29) | 252 | 2014 | R | |
| 181. | Madison Bumgarner (26) | 251 | 2016 | L |
| Don Drysdale+ (26) | 251 | 1963 | R | |
| Pedro Martinez+ (26) | 251 | 1998 | R | |
| CC Sabathia (27) | 251 | 2008 | L | |
| Jason Schmidt (31) | 251 | 2004 | R | |
| Tom Seaver+ (28) | 251 | 1973 | R | |
| Bill Stoneman (27) | 251 | 1971 | R | |
| Stephen Strasburg (30) | 251 | 2019 | R | |
| 189. | Mickey Lolich (31) | 250 | 1972 | L |
| Tony Mullane (27) | 250 | 1886 | R | |
| Bob Veale (28) | 250 | 1964 | L | |
| Justin Verlander (28) | 250 | 2011 | R | |
| 193. | Chris Archer (28) | 249 | 2017 | R |
| Bert Blyleven+ (23) | 249 | 1974 | R | |
| Tom Seaver+ (27) | 249 | 1972 | R | |
| 196. | Ron Guidry (27) | 248 | 1978 | L |
| Felix Hernandez (28) | 248 | 2014 | R | |
| Clayton Kershaw (23) | 248 | 2011 | L | |
| Juan Marichal+ (25) | 248 | 1963 | R | |
| Phil Niekro+ (39) | 248 | 1978 | R | |
| Rank | Player (age that year) | Strikeouts | Year | Throws |
| 201. | Al Atkinson (23) | 247 | 1884 | R |
| Bill Singer (25) | 247 | 1969 | R | |
| 203. | Patrick Corbin (28) | 246 | 2018 | L |
| Don Drysdale+ (23) | 246 | 1960 | R | |
| Bob Feller+ (20) | 246 | 1939 | R | |
| Jim Lonborg (25) | 246 | 1967 | R | |
| Lance Lynn (32) | 246 | 2019 | R | |
| 208. | Bob Gibson+ (28) | 245 | 1964 | R |
| Corey Kluber (29) | 245 | 2015 | R | |
| Mark Langston (25) | 245 | 1986 | L | |
| Mark Prior (22) | 245 | 2003 | R | |
| Nolan Ryan+ (35) | 245 | 1982 | R | |
| Johan Santana (27) | 245 | 2006 | L | |
| Herb Score (22) | 245 | 1955 | L | |
| 215. | Dennis Leonard (26) | 244 | 1977 | R |
| Jim Maloney (25) | 244 | 1965 | R | |
| 217. | Walter Johnson+ (25) | 243 | 1913 | R |
| Lee Richmond (23) | 243 | 1880 | L | |
| Max Scherzer (34) | 243 | 2019 | R | |
| Tom Seaver+ (30) | 243 | 1975 | R | |
| 221. | Charlie Buffinton (24) | 242 | 1885 | R |
| Johnny Cueto (28) | 242 | 2014 | R | |
| Don Drysdale+ (22) | 242 | 1959 | R | |
| Zack Greinke (25) | 242 | 2009 | R | |
| Mario Soto (26) | 242 | 1983 | R | |
| Stephen Strasburg (25) | 242 | 2014 | R | |
| Fernando Valenzuela (25) | 242 | 1986 | L | |
| 228. | Pete Alexander+ (28) | 241 | 1915 | R |
| Roger Clemens (28) | 241 | 1991 | R | |
| David Cone (28) | 241 | 1991 | R | |
| Randy Johnson+ (28) | 241 | 1992 | L | |
| Bill Singer (29) | 241 | 1973 | R | |
| John Smoltz+ (30) | 241 | 1997 | R | |
| Javier Vazquez (26) | 241 | 2003 | R | |
| 235. | Steve Carlton+ (29) | 240 | 1974 | L |
| Bob Feller+ (19) | 240 | 1938 | R | |
| Teddy Higuera (29) | 240 | 1987 | L | |
| Juan Marichal+ (27) | 240 | 1965 | R | |
| Charlie Morton (35) | 240 | 2019 | R | |
| Kid Nichols+ (21) | 240 | 1891 | R | |
| Jake Peavy (26) | 240 | 2007 | R | |
| Max Scherzer (28) | 240 | 2013 | R | |
| Fernando Valenzuela (23) | 240 | 1984 | L | |
| 244. | Jack Chesbro+ (30) | 239 | 1904 | R |
| Jacob deGrom (29) | 239 | 2017 | R | |
| Noodles Hahn (22) | 239 | 1901 | L | |
| Scott Kazmir (23) | 239 | 2007 | L | |
| Clayton Kershaw (26) | 239 | 2014 | L | |
| Pedro Martinez+ (30) | 239 | 2002 | R | |
| Oliver Perez (22) | 239 | 2004 | L | |
| Rank | Player (age that year) | Strikeouts | Year | Throws |
| Cy Seymour (25) | 239 | 1898 | L | |
| Bill Stemmyer (21) | 239 | 1886 | R | |
| Justin Verlander (29) | 239 | 2012 | R | |
| John Ward+ (19) | 239 | 1879 | R | |
| 255. | Matthew Boyd (28) | 238 | 2019 | L |
| Roger Clemens (23) | 238 | 1986 | R | |
| Patrick Corbin (29) | 238 | 2019 | L | |
| Cliff Lee (32) | 238 | 2011 | L | |
| Van Mungo (25) | 238 | 1936 | R | |
| Gaylord Perry+ (34) | 238 | 1973 | R | |
| Johan Santana (26) | 238 | 2005 | L | |
| Javier Vazquez (32) | 238 | 2009 | R | |
| 263. | John Clarkson+ (25) | 237 | 1887 | R |
| Don Drysdale+ (27) | 237 | 1964 | R | |
| Rube Marquard+ (24) | 237 | 1911 | L | |
| Chris Sale (29) | 237 | 2018 | L | |
| Chris Short (27) | 237 | 1965 | L | |
| 268. | Jake Arrieta (29) | 236 | 2015 | R |
| Joe Coleman (24) | 236 | 1971 | R | |
| Cy Falkenberg (34) | 236 | 1914 | R | |
| Fergie Jenkins+ (24) | 236 | 1967 | R | |
| Sam McDowell (24) | 236 | 1967 | L | |
| Hideo Nomo (26) | 236 | 1995 | R | |
| 274. | Mark Langston (27) | 235 | 1988 | L |
| Mark Langston (28) | 235 | 1989 | L | |
| Robbie Ray (27) | 235 | 2019 | L | |
| Johan Santana (28) | 235 | 2007 | L | |
| Tom Seaver+ (31) | 235 | 1976 | R | |
| Don Wilson (24) | 235 | 1969 | R | |
| 280. | Madison Bumgarner (25) | 234 | 2015 | L |
| Dean Chance (27) | 234 | 1968 | R | |
| Hideo Nomo (27) | 234 | 1996 | R | |
| Gaylord Perry+ (33) | 234 | 1972 | R | |
| 284. | Chris Archer (27) | 233 | 2016 | R |
| Bert Blyleven+ (24) | 233 | 1975 | R | |
| David Cone (27) | 233 | 1990 | R | |
| Hideo Nomo (28) | 233 | 1997 | R | |
| Gaylord Perry+ (30) | 233 | 1969 | R | |
| Gaylord Perry+ (36) | 233 | 1975 | R | |
| Chris Sale (27) | 233 | 2016 | L | |
| Mike Scott (32) | 233 | 1987 | R | |
| Jered Weaver (27) | 233 | 2010 | R | |
| Kerry Wood (21) | 233 | 1998 | R | |
| 294. | Larry Dierker (22) | 232 | 1969 | R |
| Don Drysdale+ (25) | 232 | 1962 | R | |
| Felix Hernandez (24) | 232 | 2010 | R | |
| Clayton Kershaw (25) | 232 | 2013 | L | |
| Jack Morris+ (28) | 232 | 1983 | R | |
| Nolan Ryan+ (43) | 232 | 1990 | R | |
| Rube Waddell+ (30) | 232 | 1907 | L | |
| Rank | Player (age that year) | Strikeouts | Year | Throws |
| Rube Waddell+ (31) | 232 | 1908 | L | |
| Will White (24) | 232 | 1879 | R | |
| 303. | A.J. Burnett (31) | 231 | 2008 | R |
| Carlos Carrasco (31) | 231 | 2018 | R | |
| Jack Flaherty (23) | 231 | 2019 | R | |
| Clay Kirby (23) | 231 | 1971 | R | |
| Tim Lincecum (26) | 231 | 2010 | R | |
| Max Scherzer (27) | 231 | 2012 | R | |
| Smoky Joe Wood (21) | 231 | 1911 | R | |
| 310. | Roger Clemens (26) | 230 | 1989 | R |
| R.A. Dickey (37) | 230 | 2012 | R | |
| Mickey Lolich (29) | 230 | 1970 | L | |
| German Marquez (23) | 230 | 2018 | R | |
| Gaylord Perry+ (28) | 230 | 1967 | R | |
| CC Sabathia (30) | 230 | 2011 | L | |
| Luis Severino (23) | 230 | 2017 | R | |
| Adonis Terry (19) | 230 | 1884 | R | |
| John Ward+ (20) | 230 | 1880 | R | |
| 319. | Yu Darvish (32) | 229 | 2019 | R |
| Dave Davenport (25) | 229 | 1915 | R | |
| Clayton Kershaw (24) | 229 | 2012 | L | |
| Aaron Nola (26) | 229 | 2019 | R | |
| Bob Veale (30) | 229 | 1966 | L | |
| 324. | Bert Blyleven+ (21) | 228 | 1972 | R |
| Lucas Giolito (24) | 228 | 2019 | R | |
| Randy Johnson+ (27) | 228 | 1991 | L | |
| Walter Johnson+ (28) | 228 | 1916 | R | |
| Phil Knell (26) | 228 | 1891 | L | |
| David Price (30) | 228 | 2016 | L | |
| Toad Ramsey (23) | 228 | 1888 | L | |
| Nolan Ryan+ (41) | 228 | 1988 | R | |
| 332. | Pete Alexander+ (24) | 227 | 1911 | R |
| Tim Keefe+ (28) | 227 | 1885 | R | |
| Corey Kluber (30) | 227 | 2016 | R | |
| Pedro Martinez+ (32) | 227 | 2004 | R | |
| Jose Rijo (28) | 227 | 1993 | R | |
| Bill Singer (24) | 227 | 1968 | R | |
| 338. | Jersey Bakley (20) | 226 | 1884 | R |
| Carlos Carrasco (30) | 226 | 2017 | R | |
| Luis Castillo (26) | 226 | 2019 | R | |
| Bill Donovan (24) | 226 | 1901 | R | |
| Mickey Lolich (24) | 226 | 1965 | L | |
| Bobo Newsom (30) | 226 | 1938 | R | |
| Chris Sale (24) | 226 | 2013 | L | |
| Tom Seaver+ (33) | 226 | 1978 | R | |
| 346. | Bob Gibson+ (30) | 225 | 1966 | R |
| Egyptian Healy (23) | 225 | 1890 | R | |
| Tom Hughes (22) | 225 | 1901 | R | |
| Fergie Jenkins+ (31) | 225 | 1974 | R | |
| Walter Johnson+ (26) | 225 | 1914 | R | |
| Rank | Player (age that year) | Strikeouts | Year | Throws |
| Sam Jones (32) | 225 | 1958 | R | |
| Tim Keefe+ (32) | 225 | 1889 | R | |
| Jon Lester (25) | 225 | 2009 | L | |
| Jon Lester (26) | 225 | 2010 | L | |
| Sam McDowell (23) | 225 | 1966 | L | |
| David Price (29) | 225 | 2015 | L | |
| James Shields (29) | 225 | 2011 | R | |
| Vic Willis+ (26) | 225 | 1902 | R | |
| 359. | Bert Blyleven+ (20) | 224 | 1971 | R |
| Jack Coombs (27) | 224 | 1910 | R | |
| Aaron Nola (25) | 224 | 2018 | R | |
| 362. | Steve Carlton+ (28) | 223 | 1973 | L |
| John Clarkson+ (26) | 223 | 1888 | R | |
| Dwight Gooden (25) | 223 | 1990 | R | |
| Dan Haren (28) | 223 | 2009 | R | |
| Felix Hernandez (26) | 223 | 2012 | R | |
| Charlie Hough (39) | 223 | 1987 | R | |
| Sandy Koufax+ (28) | 223 | 1964 | L | |
| Ramon Martinez (22) | 223 | 1990 | R | |
| Jack Morris+ (31) | 223 | 1986 | R | |
| Nolan Ryan+ (32) | 223 | 1979 | R | |
| James Shields (30) | 223 | 2012 | R | |
| 373. | Joe Coleman (25) | 222 | 1972 | R |
| David Cone (34) | 222 | 1997 | R | |
| Jeff Fassero (33) | 222 | 1996 | L | |
| Kid Gleason (23) | 222 | 1890 | R | |
| Felix Hernandez (25) | 222 | 2011 | R | |
| Corey Kluber (32) | 222 | 2018 | R | |
| Cliff Lee (34) | 222 | 2013 | L | |
| Juan Marichal+ (28) | 222 | 1966 | R | |
| Pedro Martinez+ (24) | 222 | 1996 | R | |
| Kid Nichols+ (20) | 222 | 1890 | R | |
| 383. | Trevor Bauer (27) | 221 | 2018 | R |
| Erik Bedard (28) | 221 | 2007 | L | |
| Kevin Brown (34) | 221 | 1999 | R | |
| Yu Darvish (25) | 221 | 2012 | R | |
| Christy Mathewson+ (20) | 221 | 1901 | R | |
| Andy Messersmith (28) | 221 | 1974 | R | |
| Camilo Pascual (27) | 221 | 1961 | R | |
| Blake Snell (25) | 221 | 2018 | L | |
| Dazzy Vance+ (34) | 221 | 1925 | R | |
| Bobby Witt (26) | 221 | 1990 | R | |
| 393. | Dean Chance (26) | 220 | 1967 | R |
| Roy Halladay+ (34) | 220 | 2011 | R | |
| Jon Lester (30) | 220 | 2014 | L | |
| Tim Lincecum (27) | 220 | 2011 | R | |
| Hideo Nomo (32) | 220 | 2001 | R | |
| Luis Severino (24) | 220 | 2018 | R | |
| 399. | Bert Blyleven+ (25) | 219 | 1976 | R |
| Madison Bumgarner (24) | 219 | 2014 | L | |
| Rank | Player (age that year) | Strikeouts | Year | Throws |
| Jim Bunning+ (32) | 219 | 1964 | R | |
| Roy Halladay+ (33) | 219 | 2010 | R | |
| Darryl Kile (27) | 219 | 1996 | R | |
| Sadie McMahon (23) | 219 | 1891 | R | |
| Luis Tiant (26) | 219 | 1967 | R | |
| Justin Verlander (27) | 219 | 2010 | R | |
| Justin Verlander (34) | 219 | 2017 | R | |
| Adam Wainwright (31) | 219 | 2013 | R | |
| Gus Weyhing (24) | 219 | 1891 | R | |
| 410. | Roger Clemens (41) | 218 | 2004 | R |
| Aaron Harang (29) | 218 | 2007 | R | |
| Juan Marichal+ (30) | 218 | 1968 | R | |
| Mike Mussina+ (28) | 218 | 1997 | R | |
| Chan Ho Park (28) | 218 | 2001 | R | |
| Melido Perez (26) | 218 | 1992 | R | |
| David Price (25) | 218 | 2011 | L | |
| Old Hoss Radbourn+ (31) | 218 | 1886 | R | |
| Robbie Ray (24) | 218 | 2016 | L | |
| Robbie Ray (25) | 218 | 2017 | L | |
| Chris Sale (30) | 218 | 2019 | L | |
| Noah Syndergaard (23) | 218 | 2016 | R | |
| 422. | Al Downing (23) | 217 | 1964 | L |
| Felix Hernandez (23) | 217 | 2009 | R | |
| Matt Kilroy (21) | 217 | 1887 | L | |
| Matt Kilroy (23) | 217 | 1889 | L | |
| Carlos Martinez (25) | 217 | 2017 | R | |
| Chan Ho Park (27) | 217 | 2000 | R | |
| Don Sutton+ (24) | 217 | 1969 | R | |
| Justin Verlander (30) | 217 | 2013 | R | |
| Kerry Wood (24) | 217 | 2001 | R | |
| Kerry Wood (25) | 217 | 2002 | R | |
| 432. | Kevin Brown (35) | 216 | 2000 | R |
| Carlos Carrasco (28) | 216 | 2015 | R | |
| Larry Corcoran (23) | 216 | 1883 | R | |
| Cole Hamels (28) | 216 | 2012 | L | |
| Aaron Harang (28) | 216 | 2006 | R | |
| Dan Haren (29) | 216 | 2010 | R | |
| Felix Hernandez (27) | 216 | 2013 | R | |
| Dallas Keuchel (27) | 216 | 2015 | L | |
| Sandy Koufax+ (26) | 216 | 1962 | L | |
| Jim Maloney (26) | 216 | 1966 | R | |
| Jake Peavy (24) | 216 | 2005 | R | |
| Gaylord Perry+ (35) | 216 | 1974 | R | |
| James Shields (33) | 216 | 2015 | R | |
| 445. | Bert Blyleven+ (35) | 215 | 1986 | R |
| Walker Buehler (24) | 215 | 2019 | R | |
| Matt Clement (27) | 215 | 2002 | R | |
| Chuck Finley (33) | 215 | 1996 | L | |
| Zack Greinke (33) | 215 | 2017 | R | |
| Cole Hamels (31) | 215 | 2015 | L | |
| Rank | Player (age that year) | Strikeouts | Year | Throws |
| John Montefusco (25) | 215 | 1975 | R | |
| Jake Peavy (25) | 215 | 2006 | R | |
| Gary Peters (30) | 215 | 1967 | L | |
| John Smoltz+ (25) | 215 | 1992 | R | |
| 455. | Pete Alexander+ (27) | 214 | 1914 | R |
| Ubaldo Jimenez (26) | 214 | 2010 | R | |
| Mickey Lolich (32) | 214 | 1973 | L | |
| Jim Maloney (24) | 214 | 1964 | R | |
| Mike Mussina+ (32) | 214 | 2001 | R | |
| Gaylord Perry+ (31) | 214 | 1970 | R | |
| J.R. Richard (26) | 214 | 1976 | R | |
| J.R. Richard (27) | 214 | 1977 | R | |
| Jeff Samardzija (28) | 214 | 2013 | R | |
| Ervin Santana (25) | 214 | 2008 | R | |
| Mario Soto (28) | 214 | 1985 | R | |
| 466. | Steve Carlton+ (34) | 213 | 1979 | L |
| Chris Carpenter (30) | 213 | 2005 | R | |
| Roger Clemens (38) | 213 | 2001 | R | |
| David Cone (25) | 213 | 1988 | R | |
| Egyptian Healy (19) | 213 | 1886 | R | |
| Andy Messersmith (29) | 213 | 1975 | R | |
| Camilo Pascual (30) | 213 | 1964 | R | |
| Eduardo Rodriguez (26) | 213 | 2019 | L | |
| Rick Sutcliffe (28) | 213 | 1984 | R | |
| Javier Vazquez (30) | 213 | 2007 | R | |
| Bob Veale (33) | 213 | 1969 | L | |
| Adam Wainwright (28) | 213 | 2010 | R | |
| Gus Weyhing (22) | 213 | 1889 | R | |
| 479. | Jersey Bakley (24) | 212 | 1888 | R |
| Bartolo Colon (27) | 212 | 2000 | R | |
| George Derby (23) | 212 | 1881 | R | |
| Charlie Ferguson (23) | 212 | 1886 | R | |
| Chuck Finley (35) | 212 | 1998 | L | |
| Clayton Kershaw (22) | 212 | 2010 | L | |
| Christy Mathewson+ (23) | 212 | 1904 | R | |
| Hal Newhouser+ (24) | 212 | 1945 | L | |
| Tyson Ross (28) | 212 | 2015 | R | |
| Adam Wainwright (27) | 212 | 2009 | R | |
| 489. | Tony Cloninger (24) | 211 | 1965 | R |
| Cole Hamels (26) | 211 | 2010 | L | |
| Erik Hanson (25) | 211 | 1990 | R | |
| Randy Johnson+ (41) | 211 | 2005 | L | |
| Jim Kaat (28) | 211 | 1967 | L | |
| Andy Messersmith (23) | 211 | 1969 | R | |
| John Smoltz+ (39) | 211 | 2006 | R | |
| Frank Viola (29) | 211 | 1989 | L | |
| 497. | Pedro Astacio (30) | 210 | 1999 | R |
| Steve Carlton+ (24) | 210 | 1969 | L | |
| Don Drysdale+ (28) | 210 | 1965 | R | |
| Mike Mussina+ (31) | 210 | 2000 | R | |
| Rank | Player (age that year) | Strikeouts | Year | Throws |
| Eddie Plank+ (29) | 210 | 1905 | L | |
| Bob Turley (24) | 210 | 1955 | R | |
| Rube Waddell+ (25) | 210 | 1902 | L | |
| Wilbur Wood (29) | 210 | 1971 | L | |
| Cy Young+ (38) | 210 | 1905 | R | |
| Carlos Zambrano (25) | 210 | 2006 | R |
