Single-Season Leaders & Records for Strikeouts
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| Rank | Player (age that year) | Strikeouts | Year | IP | Throws |
|---|---|---|---|---|---|
| 1. | Matt Kilroy (20) | 513 | 1886 | 583.0 | L |
| 2. | Toad Ramsey (21) | 499 | 1886 | 588.2 | L |
| 3. | Hugh Daily (36) | 483 | 1884 | 500.2 | R |
| 4. | Dupee Shaw (25) | 451 | 1884 | 543.4 | L |
| 5. | Old Hoss Radbourn+ (29) | 441 | 1884 | 678.2 | R |
| 6. | Charlie Buffinton (23) | 417 | 1884 | 587.0 | R |
| 7. | Guy Hecker (28) | 385 | 1884 | 670.2 | R |
| 8. | Nolan Ryan+ (26) | 383 | 1973 | 326.0 | R |
| 9. | Sandy Koufax+ (29) | 382 | 1965 | 335.2 | L |
| 10. | Bill Sweeney (26) | 374 | 1884 | 538.0 | R |
| 11. | Randy Johnson+ (37) | 372 | 2001 | 249.2 | L |
| 12. | Pud Galvin+ (27) | 369 | 1884 | 636.1 | R |
| 13. | Mark Baldwin (25) | 368 | 1889 | 513.2 | R |
| 14. | Nolan Ryan+ (27) | 367 | 1974 | 332.2 | R |
| 15. | Randy Johnson+ (35) | 364 | 1999 | 271.2 | L |
| 16. | Tim Keefe+ (26) | 359 | 1883 | 619.0 | R |
| 17. | Toad Ramsey (22) | 355 | 1887 | 561.0 | L |
| 18. | Rube Waddell+ (27) | 349 | 1904 | 383.0 | L |
| 19. | Bob Feller+ (27) | 348 | 1946 | 371.1 | R |
| 20. | Randy Johnson+ (36) | 347 | 2000 | 248.2 | L |
| 21. | Hardie Henderson (21) | 346 | 1884 | 439.1 | R |
| 22. | Mickey Welch+ (24) | 345 | 1884 | 557.1 | R |
| Jim Whitney (25) | 345 | 1883 | 514.0 | R | |
| 24. | Jim McCormick (27) | 343 | 1884 | 569.0 | R |
| 25. | Amos Rusie+ (19) | 341 | 1890 | 548.2 | R |
| Nolan Ryan+ (30) | 341 | 1977 | 299.0 | R | |
| 27. | Amos Rusie+ (20) | 337 | 1891 | 500.1 | R |
| Charlie Sweeney (21) | 337 | 1884 | 492.0 | R | |
| 29. | Tim Keefe+ (31) | 335 | 1888 | 434.1 | R |
| 30. | Randy Johnson+ (38) | 334 | 2002 | 260.0 | L |
| Tim Keefe+ (27) | 334 | 1884 | 483.0 | R | |
| 32. | Randy Johnson+ (34) | 329 | 1998 | 244.1 | L |
| Nolan Ryan+ (25) | 329 | 1972 | 284.0 | R | |
| 34. | Nolan Ryan+ (29) | 327 | 1976 | 284.1 | R |
| 35. | Gerrit Cole (28) | 326 | 2019 | 212.1 | R |
| Ed Morris (23) | 326 | 1886 | 555.1 | L | |
| 37. | Sam McDowell (22) | 325 | 1965 | 273.0 | L |
| Tony Mullane (25) | 325 | 1884 | 567.0 | R | |
| 39. | Lady Baldwin (27) | 323 | 1886 | 487.0 | L |
| 40. | Curt Schilling (30) | 319 | 1997 | 254.1 | R |
| 41. | Sandy Koufax+ (30) | 317 | 1966 | 323.0 | L |
| 42. | Curt Schilling (35) | 316 | 2002 | 259.1 | R |
| 43. | Old Hoss Radbourn+ (28) | 315 | 1883 | 632.1 | R |
| 44. | Bill Hutchison (32) | 314 | 1892 | 622.0 | R |
| 45. | John Clarkson+ (24) | 313 | 1886 | 466.2 | R |
| Walter Johnson+ (22) | 313 | 1910 | 370.0 | R | |
| Pedro Martinez+ (27) | 313 | 1999 | 213.1 | R | |
| J.R. Richard (29) | 313 | 1979 | 292.1 | R | |
| 49. | Steve Carlton+ (27) | 310 | 1972 | 346.1 | L |
| 50. | John Clarkson+ (23) | 308 | 1885 | 623.0 | R |
| Rank | Player (age that year) | Strikeouts | Year | IP | Throws |
| Randy Johnson+ (29) | 308 | 1993 | 255.1 | L | |
| Mickey Lolich (30) | 308 | 1971 | 376.0 | L | |
| Larry McKeon (18) | 308 | 1884 | 512.0 | ||
| Chris Sale (28) | 308 | 2017 | 214.1 | L | |
| 55. | Sandy Koufax+ (27) | 306 | 1963 | 311.0 | L |
| Mike Scott (31) | 306 | 1986 | 275.1 | R | |
| 57. | Pedro Martinez+ (25) | 305 | 1997 | 241.1 | R |
| 58. | Sam McDowell (27) | 304 | 1970 | 305.0 | L |
| Amos Rusie+ (21) | 304 | 1892 | 541.0 | R | |
| 60. | Walter Johnson+ (24) | 303 | 1912 | 369.0 | R |
| J.R. Richard (28) | 303 | 1978 | 275.1 | R | |
| 62. | Ed Morris (21) | 302 | 1884 | 429.2 | L |
| Rube Waddell+ (26) | 302 | 1903 | 324.0 | L | |
| 64. | Vida Blue (21) | 301 | 1971 | 312.0 | L |
| Clayton Kershaw (27) | 301 | 2015 | 232.2 | L | |
| Nolan Ryan+ (42) | 301 | 1989 | 239.1 | R | |
| 67. | Max Scherzer (33) | 300 | 2018 | 220.2 | R |
| Curt Schilling (31) | 300 | 1998 | 268.2 | R | |
| Justin Verlander (36) | 300 | 2019 | 223.0 | R | |
| 70. | Ed Morris (22) | 298 | 1885 | 581.0 | L |
| 71. | Tim Keefe+ (29) | 297 | 1886 | 535.0 | R |
| 72. | Randy Johnson+ (31) | 294 | 1995 | 214.1 | L |
| 73. | Curt Schilling (34) | 293 | 2001 | 256.2 | R |
| 74. | Roger Clemens (34) | 292 | 1997 | 264.0 | R |
| Jack Lynch (27) | 292 | 1884 | 496.0 | R | |
| 76. | Roger Clemens (25) | 291 | 1988 | 264.0 | R |
| Randy Johnson+ (33) | 291 | 1997 | 213.0 | L | |
| Sadie McMahon (22) | 291 | 1890 | 509.0 | R | |
| 79. | Randy Johnson+ (40) | 290 | 2004 | 245.2 | L |
| Justin Verlander (35) | 290 | 2018 | 214.0 | R | |
| 81. | Bill Hutchison (30) | 289 | 1890 | 603.0 | R |
| Tom Seaver+ (26) | 289 | 1971 | 286.1 | R | |
| Jack Stivetts (22) | 289 | 1890 | 419.1 | R | |
| 84. | Rube Waddell+ (28) | 287 | 1905 | 328.2 | L |
| 85. | Steve Carlton+ (35) | 286 | 1980 | 304.0 | L |
| Steve Carlton+ (37) | 286 | 1982 | 295.2 | L | |
| Bobby Mathews (32) | 286 | 1884 | 430.2 | R | |
| Bobby Mathews (33) | 286 | 1885 | 422.1 | R | |
| 89. | John Clarkson+ (27) | 284 | 1889 | 620.0 | R |
| Pedro Martinez+ (28) | 284 | 2000 | 217.0 | R | |
| Max Scherzer (31) | 284 | 2016 | 228.1 | R | |
| Billy Taylor (29) | 284 | 1884 | 523.0 | R | |
| 93. | Dave Foutz (29) | 283 | 1886 | 504.0 | R |
| Sam McDowell (25) | 283 | 1968 | 269.0 | L | |
| Tom Seaver+ (25) | 283 | 1970 | 290.2 | R | |
| 96. | Denny McLain (24) | 280 | 1968 | 336.0 | R |
| 97. | Pud Galvin+ (26) | 279 | 1883 | 656.1 | R |
| Sam McDowell (26) | 279 | 1969 | 285.0 | L | |
| 99. | Yu Darvish (26) | 277 | 2013 | 209.2 | R |
| 100. | Gerrit Cole (27) | 276 | 2018 | 200.1 | R |
| Rank | Player (age that year) | Strikeouts | Year | IP | Throws |
| Dwight Gooden (19) | 276 | 1984 | 218.0 | R | |
| Max Scherzer (30) | 276 | 2015 | 228.2 | R | |
| John Smoltz+ (29) | 276 | 1996 | 253.2 | R | |
| Bob Veale (29) | 276 | 1965 | 266.0 | L | |
| 105. | Steve Carlton+ (38) | 275 | 1983 | 283.2 | L |
| Hal Newhouser+ (25) | 275 | 1946 | 292.2 | L | |
| 107. | Bob Gibson+ (34) | 274 | 1970 | 294.0 | R |
| Fergie Jenkins+ (27) | 274 | 1970 | 313.0 | R | |
| Chris Sale (26) | 274 | 2015 | 208.2 | L | |
| Mario Soto (25) | 274 | 1982 | 257.2 | R | |
| 111. | Fergie Jenkins+ (26) | 273 | 1969 | 311.1 | R |
| 112. | Larry Corcoran (24) | 272 | 1884 | 516.2 | R |
| Ed Seward (21) | 272 | 1888 | 518.2 | R | |
| Mickey Welch+ (26) | 272 | 1886 | 500.0 | R | |
| 115. | Roger Clemens (35) | 271 | 1998 | 234.2 | R |
| Mickey Lolich (28) | 271 | 1969 | 280.2 | L | |
| David Price (28) | 271 | 2014 | 248.4 | L | |
| 118. | Bob Gibson+ (29) | 270 | 1965 | 299.0 | R |
| Nolan Ryan+ (40) | 270 | 1987 | 211.2 | R | |
| Jim Whitney (26) | 270 | 1884 | 336.0 | R | |
| 121. | Jacob deGrom (30) | 269 | 2018 | 217.0 | R |
| Bob Gibson+ (33) | 269 | 1969 | 314.0 | R | |
| Corey Kluber (28) | 269 | 2014 | 235.2 | R | |
| Sandy Koufax+ (25) | 269 | 1961 | 255.2 | L | |
| Frank Tanana (21) | 269 | 1975 | 257.1 | L | |
| Justin Verlander (26) | 269 | 2009 | 240.0 | R | |
| Ed Walsh+ (27) | 269 | 1908 | 464.0 | R | |
| 128. | Jim Bunning+ (33) | 268 | 1965 | 291.0 | R |
| Larry Corcoran (20) | 268 | 1880 | 536.1 | R | |
| Bob Gibson+ (32) | 268 | 1968 | 304.2 | R | |
| Dwight Gooden (20) | 268 | 1985 | 276.2 | R | |
| Max Scherzer (32) | 268 | 2017 | 200.2 | R | |
| Bill Wise (23) | 268 | 1884 | 364.1 | ||
| 134. | Christy Mathewson+ (22) | 267 | 1903 | 366.1 | R |
| 135. | Kerry Wood (26) | 266 | 2003 | 211.0 | R |
| 136. | Corey Kluber (31) | 265 | 2017 | 203.2 | R |
| Tim Lincecum (24) | 265 | 2008 | 227.0 | R | |
| Jim Maloney (23) | 265 | 1963 | 250.1 | R | |
| Johan Santana (25) | 265 | 2004 | 228.0 | L | |
| 140. | Bob Emslie (25) | 264 | 1884 | 455.1 | R |
| Ben Sheets (25) | 264 | 2004 | 237.0 | R | |
| Luis Tiant (27) | 264 | 1968 | 258.1 | R | |
| 143. | Hardie Henderson (22) | 263 | 1885 | 539.1 | R |
| Fergie Jenkins+ (28) | 263 | 1971 | 325.0 | R | |
| Herb Score (23) | 263 | 1956 | 249.1 | L | |
| 146. | Mark Langston (26) | 262 | 1987 | 272.0 | L |
| Phil Niekro+ (38) | 262 | 1977 | 330.1 | R | |
| Dazzy Vance+ (33) | 262 | 1924 | 308.1 | R | |
| 149. | David Cone (29) | 261 | 1992 | 249.2 | R |
| Bob Feller+ (21) | 261 | 1940 | 320.1 | R | |
| Rank | Player (age that year) | Strikeouts | Year | IP | Throws |
| Bill Hutchison (31) | 261 | 1891 | 561.0 | R | |
| Tim Lincecum (25) | 261 | 2009 | 225.1 | R | |
| Frank Tanana (22) | 261 | 1976 | 288.1 | L | |
| 154. | Bob Feller+ (22) | 260 | 1941 | 343.0 | R |
| Fergie Jenkins+ (25) | 260 | 1968 | 308.0 | R | |
| Jim McCormick (23) | 260 | 1880 | 657.2 | R | |
| Nolan Ryan+ (31) | 260 | 1978 | 234.2 | R | |
| 158. | Shane Bieber (24) | 259 | 2019 | 214.1 | R |
| Christy Mathewson+ (27) | 259 | 1908 | 390.2 | R | |
| Jack Stivetts (23) | 259 | 1891 | 440.0 | R | |
| 161. | Bert Blyleven+ (22) | 258 | 1973 | 325.0 | R |
| Silver King (20) | 258 | 1888 | 584.2 | R | |
| Ed Walsh+ (29) | 258 | 1910 | 369.2 | R | |
| Mickey Welch+ (25) | 258 | 1885 | 492.0 | R | |
| Smoky Joe Wood (22) | 258 | 1912 | 344.0 | R | |
| 166. | Kevin Brown (33) | 257 | 1998 | 257.0 | R |
| Roger Clemens (33) | 257 | 1996 | 242.2 | R | |
| Gerrit Cole (31) | 257 | 2022 | 200.2 | R | |
| Toad Ramsey (25) | 257 | 1890 | 348.2 | L | |
| 170. | Roger Clemens (24) | 256 | 1987 | 281.2 | R |
| 171. | James Burke | 255 | 1884 | 322.0 | |
| Jacob deGrom (31) | 255 | 2019 | 204.0 | R | |
| Ed Walsh+ (30) | 255 | 1911 | 368.2 | R | |
| 174. | Justin Verlander (33) | 254 | 2016 | 227.2 | R |
| Ed Walsh+ (31) | 254 | 1912 | 393.0 | R | |
| 176. | Trevor Bauer (28) | 253 | 2019 | 213.0 | R |
| Jim Bunning+ (35) | 253 | 1967 | 302.1 | R | |
| José Fernández (23) | 253 | 2016 | 182.1 | R | |
| 179. | Chris Archer (26) | 252 | 2015 | 212.0 | R |
| Jim Bunning+ (34) | 252 | 1966 | 314.0 | R | |
| Max Scherzer (29) | 252 | 2014 | 220.1 | R | |
| 182. | Madison Bumgarner (26) | 251 | 2016 | 226.2 | L |
| Don Drysdale+ (26) | 251 | 1963 | 315.1 | R | |
| Pedro Martinez+ (26) | 251 | 1998 | 233.2 | R | |
| CC Sabathia (27) | 251 | 2008 | 253.0 | L | |
| Jason Schmidt (31) | 251 | 2004 | 225.0 | R | |
| Tom Seaver+ (28) | 251 | 1973 | 290.0 | R | |
| Bill Stoneman (27) | 251 | 1971 | 294.2 | R | |
| Stephen Strasburg (30) | 251 | 2019 | 209.0 | R | |
| 190. | Mickey Lolich (31) | 250 | 1972 | 327.1 | L |
| Tony Mullane (27) | 250 | 1886 | 529.2 | R | |
| Bob Veale (28) | 250 | 1964 | 279.2 | L | |
| Justin Verlander (28) | 250 | 2011 | 251.0 | R | |
| 194. | Chris Archer (28) | 249 | 2017 | 201.0 | R |
| Bert Blyleven+ (23) | 249 | 1974 | 281.0 | R | |
| Tom Seaver+ (27) | 249 | 1972 | 262.0 | R | |
| 197. | Ron Guidry (27) | 248 | 1978 | 273.2 | L |
| Félix Hernández (28) | 248 | 2014 | 236.0 | R | |
| Clayton Kershaw (23) | 248 | 2011 | 233.1 | L | |
| Juan Marichal+ (25) | 248 | 1963 | 321.1 | R | |
| Rank | Player (age that year) | Strikeouts | Year | IP | Throws |
| Phil Niekro+ (39) | 248 | 1978 | 334.1 | R | |
| Robbie Ray (29) | 248 | 2021 | 193.1 | L | |
| 203. | Al Atkinson (23) | 247 | 1884 | 393.2 | R |
| Bill Singer (25) | 247 | 1969 | 315.2 | R | |
| Zack Wheeler (31) | 247 | 2021 | 213.1 | R | |
| 206. | Patrick Corbin (28) | 246 | 2018 | 200.0 | L |
| Don Drysdale+ (23) | 246 | 1960 | 269.0 | R | |
| Bob Feller+ (20) | 246 | 1939 | 296.2 | R | |
| Jim Lonborg (25) | 246 | 1967 | 273.1 | R | |
| Lance Lynn (32) | 246 | 2019 | 208.1 | R | |
| 211. | Bob Gibson+ (28) | 245 | 1964 | 287.1 | R |
| Corey Kluber (29) | 245 | 2015 | 222.0 | R | |
| Mark Langston (25) | 245 | 1986 | 239.1 | L | |
| Mark Prior (22) | 245 | 2003 | 211.1 | R | |
| Nolan Ryan+ (35) | 245 | 1982 | 250.1 | R | |
| Johan Santana (27) | 245 | 2006 | 233.2 | L | |
| Herb Score (22) | 245 | 1955 | 227.1 | L | |
| 218. | Dennis Leonard (26) | 244 | 1977 | 292.2 | R |
| Jim Maloney (25) | 244 | 1965 | 255.1 | R | |
| 220. | Corbin Burnes (27) | 243 | 2022 | 202.0 | R |
| Gerrit Cole (30) | 243 | 2021 | 181.1 | R | |
| Walter Johnson+ (25) | 243 | 1913 | 346.0 | R | |
| Lee Richmond (23) | 243 | 1880 | 590.2 | L | |
| Max Scherzer (34) | 243 | 2019 | 172.1 | R | |
| Tom Seaver+ (30) | 243 | 1975 | 280.1 | R | |
| 226. | Charlie Buffinton (24) | 242 | 1885 | 434.1 | R |
| Johnny Cueto (28) | 242 | 2014 | 243.2 | R | |
| Don Drysdale+ (22) | 242 | 1959 | 270.2 | R | |
| Zack Greinke (25) | 242 | 2009 | 229.1 | R | |
| Mario Soto (26) | 242 | 1983 | 273.2 | R | |
| Stephen Strasburg (25) | 242 | 2014 | 215.0 | R | |
| Fernando Valenzuela (25) | 242 | 1986 | 269.1 | L | |
| 233. | Pete Alexander+ (28) | 241 | 1915 | 376.1 | R |
| Roger Clemens (28) | 241 | 1991 | 271.1 | R | |
| David Cone (28) | 241 | 1991 | 232.2 | R | |
| Randy Johnson+ (28) | 241 | 1992 | 210.1 | L | |
| Bill Singer (29) | 241 | 1973 | 315.2 | R | |
| John Smoltz+ (30) | 241 | 1997 | 256.0 | R | |
| Javier Vazquez (26) | 241 | 2003 | 230.2 | R | |
| 240. | Steve Carlton+ (29) | 240 | 1974 | 291.0 | L |
| Bob Feller+ (19) | 240 | 1938 | 277.2 | R | |
| Teddy Higuera (29) | 240 | 1987 | 261.2 | L | |
| Juan Marichal+ (27) | 240 | 1965 | 295.1 | R | |
| Charlie Morton (35) | 240 | 2019 | 194.2 | R | |
| Kid Nichols+ (21) | 240 | 1891 | 425.1 | R | |
| Jake Peavy (26) | 240 | 2007 | 223.1 | R | |
| Max Scherzer (28) | 240 | 2013 | 214.1 | R | |
| Fernando Valenzuela (23) | 240 | 1984 | 261.0 | L | |
| 249. | Jack Chesbro+ (30) | 239 | 1904 | 454.2 | R |
| Jacob deGrom (29) | 239 | 2017 | 201.1 | R | |
| Rank | Player (age that year) | Strikeouts | Year | IP | Throws |
| Noodles Hahn (22) | 239 | 1901 | 375.1 | L | |
| Scott Kazmir (23) | 239 | 2007 | 206.2 | L | |
| Clayton Kershaw (26) | 239 | 2014 | 198.1 | L | |
| Pedro Martinez+ (30) | 239 | 2002 | 199.1 | R | |
| Oliver Pérez (22) | 239 | 2004 | 196.0 | L | |
| Cy Seymour (25) | 239 | 1898 | 356.2 | L | |
| Bill Stemmyer (21) | 239 | 1886 | 348.2 | R | |
| Justin Verlander (29) | 239 | 2012 | 238.1 | R | |
| John Ward+ (19) | 239 | 1879 | 587.0 | R | |
| 260. | Matthew Boyd (28) | 238 | 2019 | 185.1 | L |
| Roger Clemens (23) | 238 | 1986 | 254.0 | R | |
| Patrick Corbin (29) | 238 | 2019 | 202.0 | L | |
| Cliff Lee (32) | 238 | 2011 | 232.2 | L | |
| Van Mungo (25) | 238 | 1936 | 311.2 | R | |
| Gaylord Perry+ (34) | 238 | 1973 | 344.0 | R | |
| Johan Santana (26) | 238 | 2005 | 231.2 | L | |
| Javier Vazquez (32) | 238 | 2009 | 219.1 | R | |
| 268. | John Clarkson+ (25) | 237 | 1887 | 523.0 | R |
| Don Drysdale+ (27) | 237 | 1964 | 321.1 | R | |
| Rube Marquard+ (24) | 237 | 1911 | 277.2 | L | |
| Carlos Rodón (29) | 237 | 2022 | 178.0 | L | |
| Chris Sale (29) | 237 | 2018 | 158.0 | L | |
| Chris Short (27) | 237 | 1965 | 297.1 | L | |
| 274. | Jake Arrieta (29) | 236 | 2015 | 229.0 | R |
| Joe Coleman (24) | 236 | 1971 | 286.0 | R | |
| Cy Falkenberg (34) | 236 | 1914 | 377.1 | R | |
| Fergie Jenkins+ (24) | 236 | 1967 | 289.1 | R | |
| Sam McDowell (24) | 236 | 1967 | 236.1 | L | |
| Hideo Nomo (26) | 236 | 1995 | 191.1 | R | |
| Max Scherzer (36) | 236 | 2021 | 179.1 | R | |
| 281. | Mark Langston (27) | 235 | 1988 | 261.1 | L |
| Mark Langston (28) | 235 | 1989 | 250.0 | L | |
| Aaron Nola (29) | 235 | 2022 | 205.0 | R | |
| Robbie Ray (27) | 235 | 2019 | 174.1 | L | |
| Johan Santana (28) | 235 | 2007 | 219.0 | L | |
| Tom Seaver+ (31) | 235 | 1976 | 271.0 | R | |
| Don Wilson (24) | 235 | 1969 | 225.0 | R | |
| 288. | Madison Bumgarner (25) | 234 | 2015 | 218.1 | L |
| Corbin Burnes (26) | 234 | 2021 | 167.0 | R | |
| Dean Chance (27) | 234 | 1968 | 292.0 | R | |
| Hideo Nomo (27) | 234 | 1996 | 228.1 | R | |
| Gaylord Perry+ (33) | 234 | 1972 | 342.2 | R | |
| 293. | Chris Archer (27) | 233 | 2016 | 201.1 | R |
| Bert Blyleven+ (24) | 233 | 1975 | 275.2 | R | |
| David Cone (27) | 233 | 1990 | 211.2 | R | |
| Hideo Nomo (28) | 233 | 1997 | 207.1 | R | |
| Gaylord Perry+ (30) | 233 | 1969 | 325.1 | R | |
| Gaylord Perry+ (36) | 233 | 1975 | 305.2 | R | |
| Chris Sale (27) | 233 | 2016 | 226.2 | L | |
| Mike Scott (32) | 233 | 1987 | 247.2 | R | |
| Rank | Player (age that year) | Strikeouts | Year | IP | Throws |
| Jered Weaver (27) | 233 | 2010 | 224.1 | R | |
| Kerry Wood (21) | 233 | 1998 | 166.2 | R | |
| 303. | Larry Dierker (22) | 232 | 1969 | 305.1 | R |
| Don Drysdale+ (25) | 232 | 1962 | 314.1 | R | |
| Félix Hernández (24) | 232 | 2010 | 249.2 | R | |
| Clayton Kershaw (25) | 232 | 2013 | 236.0 | L | |
| Jack Morris+ (28) | 232 | 1983 | 293.2 | R | |
| Nolan Ryan+ (43) | 232 | 1990 | 204.0 | R | |
| Rube Waddell+ (30) | 232 | 1907 | 284.2 | L | |
| Rube Waddell+ (31) | 232 | 1908 | 285.2 | L | |
| Will White (24) | 232 | 1879 | 680.0 | R | |
| 312. | A.J. Burnett (31) | 231 | 2008 | 221.1 | R |
| Carlos Carrasco (31) | 231 | 2018 | 192.0 | R | |
| Jack Flaherty (23) | 231 | 2019 | 196.1 | R | |
| Clay Kirby (23) | 231 | 1971 | 267.1 | R | |
| Tim Lincecum (26) | 231 | 2010 | 212.1 | R | |
| Max Scherzer (27) | 231 | 2012 | 187.2 | R | |
| Smoky Joe Wood (21) | 231 | 1911 | 275.2 | R | |
| 319. | Roger Clemens (26) | 230 | 1989 | 253.1 | R |
| R.A. Dickey (37) | 230 | 2012 | 233.2 | R | |
| Mickey Lolich (29) | 230 | 1970 | 272.2 | L | |
| Germán Márquez (23) | 230 | 2018 | 196.0 | R | |
| Gaylord Perry+ (28) | 230 | 1967 | 293.0 | R | |
| CC Sabathia (30) | 230 | 2011 | 237.1 | L | |
| Luis Severino (23) | 230 | 2017 | 193.1 | R | |
| Adonis Terry (19) | 230 | 1884 | 476.0 | R | |
| John Ward+ (20) | 230 | 1880 | 595.0 | R | |
| 328. | Yu Darvish (32) | 229 | 2019 | 178.2 | R |
| Dave Davenport (25) | 229 | 1915 | 392.2 | R | |
| Clayton Kershaw (24) | 229 | 2012 | 227.2 | L | |
| Aaron Nola (26) | 229 | 2019 | 202.1 | R | |
| Bob Veale (30) | 229 | 1966 | 268.1 | L | |
| 333. | Bert Blyleven+ (21) | 228 | 1972 | 287.1 | R |
| Lucas Giolito (24) | 228 | 2019 | 176.2 | R | |
| Randy Johnson+ (27) | 228 | 1991 | 201.1 | L | |
| Walter Johnson+ (28) | 228 | 1916 | 369.2 | R | |
| Phil Knell (26) | 228 | 1891 | 462.0 | L | |
| David Price (30) | 228 | 2016 | 230.0 | L | |
| Toad Ramsey (23) | 228 | 1888 | 342.1 | L | |
| Nolan Ryan+ (41) | 228 | 1988 | 220.0 | R | |
| 341. | Pete Alexander+ (24) | 227 | 1911 | 367.0 | R |
| Dylan Cease (26) | 227 | 2022 | 184.0 | R | |
| Kevin Gausman (30) | 227 | 2021 | 192.0 | R | |
| Tim Keefe+ (28) | 227 | 1885 | 400.0 | R | |
| Corey Kluber (30) | 227 | 2016 | 215.0 | R | |
| Pedro Martinez+ (32) | 227 | 2004 | 217.0 | R | |
| Jose Rijo (28) | 227 | 1993 | 257.1 | R | |
| Bill Singer (24) | 227 | 1968 | 256.1 | R | |
| 349. | Jersey Bakley (20) | 226 | 1884 | 394.2 | R |
| Carlos Carrasco (30) | 226 | 2017 | 200.0 | R | |
| Rank | Player (age that year) | Strikeouts | Year | IP | Throws |
| Luis Castillo (26) | 226 | 2019 | 190.2 | R | |
| Dylan Cease (25) | 226 | 2021 | 165.2 | R | |
| Bill Donovan (24) | 226 | 1901 | 351.0 | R | |
| Mickey Lolich (24) | 226 | 1965 | 243.2 | L | |
| Bobo Newsom (30) | 226 | 1938 | 329.2 | R | |
| Chris Sale (24) | 226 | 2013 | 214.1 | L | |
| Tom Seaver+ (33) | 226 | 1978 | 259.2 | R | |
| 358. | Bob Gibson+ (30) | 225 | 1966 | 280.1 | R |
| Egyptian Healy (23) | 225 | 1890 | 389.0 | R | |
| Tom Hughes (22) | 225 | 1901 | 308.1 | R | |
| Fergie Jenkins+ (31) | 225 | 1974 | 328.1 | R | |
| Walter Johnson+ (26) | 225 | 1914 | 371.2 | R | |
| Sam Jones (32) | 225 | 1958 | 250.0 | R | |
| Tim Keefe+ (32) | 225 | 1889 | 364.0 | R | |
| Jon Lester (25) | 225 | 2009 | 203.1 | L | |
| Jon Lester (26) | 225 | 2010 | 208.0 | L | |
| Sam McDowell (23) | 225 | 1966 | 194.1 | L | |
| David Price (29) | 225 | 2015 | 220.1 | L | |
| James Shields (29) | 225 | 2011 | 249.1 | R | |
| Vic Willis+ (26) | 225 | 1902 | 410.0 | R | |
| 371. | Bert Blyleven+ (20) | 224 | 1971 | 278.1 | R |
| Jack Coombs (27) | 224 | 1910 | 353.0 | R | |
| Aaron Nola (25) | 224 | 2018 | 212.1 | R | |
| 374. | Steve Carlton+ (28) | 223 | 1973 | 293.1 | L |
| John Clarkson+ (26) | 223 | 1888 | 483.1 | R | |
| Dwight Gooden (25) | 223 | 1990 | 232.2 | R | |
| Dan Haren (28) | 223 | 2009 | 229.1 | R | |
| Félix Hernández (26) | 223 | 2012 | 232.0 | R | |
| Charlie Hough (39) | 223 | 1987 | 285.1 | R | |
| Sandy Koufax+ (28) | 223 | 1964 | 223.0 | L | |
| Ramon Martinez (22) | 223 | 1990 | 234.1 | R | |
| Jack Morris+ (31) | 223 | 1986 | 267.0 | R | |
| Aaron Nola (28) | 223 | 2021 | 180.2 | R | |
| Nolan Ryan+ (32) | 223 | 1979 | 222.2 | R | |
| James Shields (30) | 223 | 2012 | 227.2 | R | |
| 386. | Joe Coleman (25) | 222 | 1972 | 280.0 | R |
| David Cone (34) | 222 | 1997 | 195.0 | R | |
| Jeff Fassero (33) | 222 | 1996 | 231.2 | L | |
| Kid Gleason (23) | 222 | 1890 | 506.0 | R | |
| Félix Hernández (25) | 222 | 2011 | 233.2 | R | |
| Corey Kluber (32) | 222 | 2018 | 215.0 | R | |
| Cliff Lee (34) | 222 | 2013 | 222.2 | L | |
| Juan Marichal+ (28) | 222 | 1966 | 307.1 | R | |
| Pedro Martinez+ (24) | 222 | 1996 | 216.2 | R | |
| Kid Nichols+ (20) | 222 | 1890 | 424.0 | R | |
| 396. | Trevor Bauer (27) | 221 | 2018 | 175.1 | R |
| Erik Bedard (28) | 221 | 2007 | 182.0 | L | |
| Kevin Brown (34) | 221 | 1999 | 252.1 | R | |
| Yu Darvish (25) | 221 | 2012 | 191.1 | R | |
| Christy Mathewson+ (20) | 221 | 1901 | 336.0 | R | |
| Rank | Player (age that year) | Strikeouts | Year | IP | Throws |
| Andy Messersmith (28) | 221 | 1974 | 292.1 | R | |
| Camilo Pascual (27) | 221 | 1961 | 252.1 | R | |
| Blake Snell (25) | 221 | 2018 | 180.2 | L | |
| Dazzy Vance+ (34) | 221 | 1925 | 265.1 | R | |
| Bobby Witt (26) | 221 | 1990 | 222.0 | R | |
| 406. | Dean Chance (26) | 220 | 1967 | 283.2 | R |
| Roy Halladay+ (34) | 220 | 2011 | 233.2 | R | |
| Jon Lester (30) | 220 | 2014 | 219.2 | L | |
| Tim Lincecum (27) | 220 | 2011 | 217.0 | R | |
| Hideo Nomo (32) | 220 | 2001 | 198.0 | R | |
| Luis Severino (24) | 220 | 2018 | 191.1 | R | |
| 412. | Bert Blyleven+ (25) | 219 | 1976 | 297.2 | R |
| Madison Bumgarner (24) | 219 | 2014 | 217.1 | L | |
| Jim Bunning+ (32) | 219 | 1964 | 284.1 | R | |
| Roy Halladay+ (33) | 219 | 2010 | 250.2 | R | |
| Darryl Kile (27) | 219 | 1996 | 219.0 | R | |
| Sadie McMahon (23) | 219 | 1891 | 503.0 | R | |
| Shohei Ohtani (27) | 219 | 2022 | 166.0 | R | |
| Luis Tiant (26) | 219 | 1967 | 213.2 | R | |
| Justin Verlander (27) | 219 | 2010 | 224.1 | R | |
| Justin Verlander (34) | 219 | 2017 | 206.0 | R | |
| Adam Wainwright (31) | 219 | 2013 | 241.2 | R | |
| Gus Weyhing (24) | 219 | 1891 | 450.0 | R | |
| 424. | Roger Clemens (41) | 218 | 2004 | 214.1 | R |
| Aaron Harang (29) | 218 | 2007 | 231.2 | R | |
| Juan Marichal+ (30) | 218 | 1968 | 325.2 | R | |
| Mike Mussina+ (28) | 218 | 1997 | 224.2 | R | |
| Chan Ho Park (28) | 218 | 2001 | 234.0 | R | |
| Melido Perez (26) | 218 | 1992 | 247.2 | R | |
| David Price (25) | 218 | 2011 | 224.1 | L | |
| Old Hoss Radbourn+ (31) | 218 | 1886 | 509.1 | R | |
| Robbie Ray (24) | 218 | 2016 | 174.1 | L | |
| Robbie Ray (25) | 218 | 2017 | 162.0 | L | |
| Chris Sale (30) | 218 | 2019 | 147.1 | L | |
| Noah Syndergaard (23) | 218 | 2016 | 183.2 | R | |
| 436. | Al Downing (23) | 217 | 1964 | 244.0 | L |
| Félix Hernández (23) | 217 | 2009 | 238.2 | R | |
| Matt Kilroy (21) | 217 | 1887 | 589.1 | L | |
| Matt Kilroy (23) | 217 | 1889 | 480.2 | L | |
| Carlos Martinez (25) | 217 | 2017 | 205.0 | R | |
| Chan Ho Park (27) | 217 | 2000 | 226.0 | R | |
| Don Sutton+ (24) | 217 | 1969 | 293.1 | R | |
| Justin Verlander (30) | 217 | 2013 | 218.1 | R | |
| Kerry Wood (24) | 217 | 2001 | 174.1 | R | |
| Kerry Wood (25) | 217 | 2002 | 213.2 | R | |
| 446. | Kevin Brown (35) | 216 | 2000 | 230.0 | R |
| Carlos Carrasco (28) | 216 | 2015 | 183.2 | R | |
| Larry Corcoran (23) | 216 | 1883 | 473.2 | R | |
| Cole Hamels (28) | 216 | 2012 | 215.1 | L | |
| Aaron Harang (28) | 216 | 2006 | 234.1 | R | |
| Rank | Player (age that year) | Strikeouts | Year | IP | Throws |
| Dan Haren (29) | 216 | 2010 | 235.0 | R | |
| Félix Hernández (27) | 216 | 2013 | 204.1 | R | |
| Dallas Keuchel (27) | 216 | 2015 | 232.0 | L | |
| Sandy Koufax+ (26) | 216 | 1962 | 184.1 | L | |
| Jim Maloney (26) | 216 | 1966 | 224.2 | R | |
| Charlie Morton (37) | 216 | 2021 | 185.2 | R | |
| Jake Peavy (24) | 216 | 2005 | 203.0 | R | |
| Gaylord Perry+ (35) | 216 | 1974 | 322.1 | R | |
| James Shields (33) | 216 | 2015 | 202.1 | R | |
| 460. | Bert Blyleven+ (35) | 215 | 1986 | 271.2 | R |
| Walker Buehler (24) | 215 | 2019 | 182.1 | R | |
| Matt Clement (27) | 215 | 2002 | 205.0 | R | |
| Chuck Finley (33) | 215 | 1996 | 238.0 | L | |
| Zack Greinke (33) | 215 | 2017 | 202.1 | R | |
| Cole Hamels (31) | 215 | 2015 | 212.4 | L | |
| John Montefusco (25) | 215 | 1975 | 243.2 | R | |
| Jake Peavy (25) | 215 | 2006 | 202.1 | R | |
| Gary Peters (30) | 215 | 1967 | 260.0 | L | |
| John Smoltz+ (25) | 215 | 1992 | 246.2 | R | |
| 470. | Pete Alexander+ (27) | 214 | 1914 | 355.0 | R |
| Ubaldo Jiménez (26) | 214 | 2010 | 221.2 | R | |
| Mickey Lolich (32) | 214 | 1973 | 308.2 | L | |
| Jim Maloney (24) | 214 | 1964 | 216.0 | R | |
| Mike Mussina+ (32) | 214 | 2001 | 228.2 | R | |
| Gaylord Perry+ (31) | 214 | 1970 | 328.2 | R | |
| J.R. Richard (26) | 214 | 1976 | 291.0 | R | |
| J.R. Richard (27) | 214 | 1977 | 267.0 | R | |
| Jeff Samardzija (28) | 214 | 2013 | 213.2 | R | |
| Ervin Santana (25) | 214 | 2008 | 219.0 | R | |
| Mario Soto (28) | 214 | 1985 | 256.2 | R | |
| 481. | Steve Carlton+ (34) | 213 | 1979 | 251.0 | L |
| Chris Carpenter (30) | 213 | 2005 | 241.2 | R | |
| Roger Clemens (38) | 213 | 2001 | 220.1 | R | |
| David Cone (25) | 213 | 1988 | 231.1 | R | |
| Egyptian Healy (19) | 213 | 1886 | 353.2 | R | |
| Andy Messersmith (29) | 213 | 1975 | 321.2 | R | |
| Camilo Pascual (30) | 213 | 1964 | 267.1 | R | |
| Eduardo Rodriguez (26) | 213 | 2019 | 203.1 | L | |
| Rick Sutcliffe (28) | 213 | 1984 | 244.2 | R | |
| Javier Vazquez (30) | 213 | 2007 | 216.2 | R | |
| Bob Veale (33) | 213 | 1969 | 225.2 | L | |
| Adam Wainwright (28) | 213 | 2010 | 230.1 | R | |
| Gus Weyhing (22) | 213 | 1889 | 449.0 | R | |
| 494. | Jersey Bakley (24) | 212 | 1888 | 532.2 | R |
| Walker Buehler (26) | 212 | 2021 | 207.2 | R | |
| Bartolo Colon (27) | 212 | 2000 | 188.0 | R | |
| George Derby (23) | 212 | 1881 | 494.2 | R | |
| Charlie Ferguson (23) | 212 | 1886 | 395.2 | R | |
| Chuck Finley (35) | 212 | 1998 | 223.1 | L | |
| Clayton Kershaw (22) | 212 | 2010 | 204.1 | L | |
| Rank | Player (age that year) | Strikeouts | Year | IP | Throws |
| Christy Mathewson+ (23) | 212 | 1904 | 367.2 | R | |
| Hal Newhouser+ (24) | 212 | 1945 | 313.1 | L | |
| Robbie Ray (30) | 212 | 2022 | 189.0 | L | |
| Tyson Ross (28) | 212 | 2015 | 196.0 | R | |
| Adam Wainwright (27) | 212 | 2009 | 233.0 | R |
