Lori Webb was the first woman to be president of a minor league.
Webb was hired by the Southern League in 1994 as Executive Assistant to the President. She moved up to Vice President of Operations in October 2000. She was co-recipient of the Rawlings Woman Executive of the Year Award in 2001. In 2012, she was voted as the SL's president, succeeding Don Mincher.
Source: MILB.com bio