MLB Scores and Standings Sunday, May 21, 1978
| St. Louis Cardinals | 2 | Final |
| Chicago Cubs | 3 |
| W | Rick Reuschel (4-3) |
| L | Mark Littell (1-6) |
| S | Bruce Sutter (5) |
| San Diego Padres | 7 | Final |
| Cincinnati Reds | 2 |
| W | Bob Shirley (2-4) |
| L | Manny Sarmiento (3-2) |
| San Diego Padres | 0 | Final |
| Cincinnati Reds | 1 |
| W | Tom Seaver (3-4) |
| L | John D'Acquisto (1-1) |
| S | Doug Bair (6) |
| Baltimore Orioles | 3 | Final |
| Cleveland Indians | 0 |
| W | Scott McGregor (3-3) |
| L | Rick Waits (3-3) |
| Baltimore Orioles | 2 | Final |
| Cleveland Indians | 3 |
| W | David Clyde (2-0) |
| L | Nelson Briles (1-3) |
| S | Dennis Kinney (5) |
| Boston Red Sox | 1 | Final |
| Detroit Tigers | 2 |
| W | Milt Wilcox (3-1) |
| L | Bill Lee (6-1) |
| Boston Red Sox | 9 | Final |
| Detroit Tigers | 3 |
| W | Luis Tiant (2-0) |
| L | Dave Rozema (2-2) |
| Atlanta Braves | 6 | Final |
| Houston Astros | 4 |
| W | Phil Niekro (4-6) |
| L | Mark Lemongello (3-5) |
| S | Adrian Devine (2) |
| Minnesota Twins | 3 | Final |
| Kansas City Royals | 2 |
| W | Gary Serum (3-0) |
| L | Paul Splittorff (4-4) |
| S | Mike Marshall (3) |
| San Francisco Giants | 1 | Final |
| Los Angeles Dodgers | 4 |
| W | Burt Hooton (3-4) |
| L | Bob Knepper (5-2) |
| S | Terry Forster (7) |
| California Angels | 1 | Final |
| Milwaukee Brewers | 2 |
| W | Lary Sorensen (5-3) |
| L | Dave LaRoche (3-1) |
| Pittsburgh Pirates | 7 | Final |
| Montreal Expos | 0 |
| W | John Candelaria (3-6) |
| L | Ross Grimsley (6-2) |
| S | Kent Tekulve (3) |
| Philadelphia Phillies | 5 | Final |
| New York Mets | 6 | (10) |
| W | Skip Lockwood (4-3) |
| L | Tug McGraw (2-3) |
| Chicago White Sox | 6 | Final |
| Oakland Athletics | 2 |
| W | Steve Stone (3-2) |
| L | Bob Lacey (3-2) |
| S | Jim Willoughby (2) |
| Chicago White Sox | 0 | Final |
| Oakland Athletics | 8 |
| W | John Henry Johnson (4-2) |
| L | Francisco Barrios (1-5) |
| Texas Rangers | 5 | Final |
| Seattle Mariners | 4 |
| W | Doyle Alexander (4-2) |
| L | Enrique Romo (3-1) |
| S | Reggie Cleveland (4) |
| New York Yankees | 2 | Final |
| Toronto Blue Jays | 1 |
| W | Ed Figueroa (5-1) |
| L | Tom Underwood (1-4) |
| S | Rich Gossage (6) |
| New York Yankees | 9 | Final |
| Toronto Blue Jays | 1 |
| W | Ken Clay (1-2) |
| L | Jerry Garvin (2-2) |
Standings Up to and Including this Date
AL East Division
AL West Division
NL East Division
AL Overall
| Tm | W | L | GB | RS | RA | pythW-L% | |
|---|---|---|---|---|---|---|---|
| DET | 23 | 12 | .657 | -- | 188 | 141 | .629 |
| BOS | 25 | 14 | .641 | -- | 213 | 162 | .623 |
| NYY | 23 | 14 | .622 | 1.0 | 166 | 133 | .600 |
| OAK | 24 | 15 | .615 | 1.0 | 133 | 124 | .532 |
| CAL | 21 | 16 | .568 | 3.0 | 166 | 138 | .584 |
| TEX | 19 | 17 | .528 | 4.5 | 143 | 148 | .484 |
| KCR | 19 | 17 | .528 | 4.5 | 155 | 152 | .509 |
| CLE | 18 | 19 | .486 | 6.0 | 149 | 152 | .491 |
| MIL | 18 | 19 | .486 | 6.0 | 191 | 176 | .537 |
| BAL | 16 | 21 | .432 | 8.0 | 150 | 196 | .380 |
| MIN | 15 | 24 | .385 | 10.0 | 181 | 188 | .483 |
| TOR | 14 | 23 | .378 | 10.0 | 148 | 198 | .370 |
| CHW | 12 | 23 | .343 | 11.0 | 135 | 167 | .404 |
| SEA | 14 | 27 | .341 | 12.0 | 154 | 197 | .389 |
NL Overall
| Tm | W | L | GB | RS | RA | pythW-L% | |
|---|---|---|---|---|---|---|---|
| SFG | 23 | 14 | .622 | -- | 143 | 130 | .543 |
| LAD | 23 | 15 | .605 | 0.5 | 203 | 147 | .644 |
| CIN | 24 | 16 | .600 | 0.5 | 200 | 182 | .543 |
| PHI | 19 | 16 | .543 | 3.0 | 174 | 133 | .621 |
| CHC | 19 | 17 | .528 | 3.5 | 143 | 152 | .472 |
| HOU | 18 | 18 | .500 | 4.5 | 146 | 141 | .516 |
| MON | 18 | 19 | .486 | 5.0 | 148 | 149 | .497 |
| PIT | 18 | 19 | .486 | 5.0 | 153 | 161 | .477 |
| NYM | 18 | 22 | .450 | 6.5 | 146 | 167 | .439 |
| SDP | 17 | 21 | .447 | 6.5 | 132 | 152 | .436 |
| ATL | 14 | 22 | .389 | 8.5 | 107 | 163 | .316 |
| STL | 14 | 26 | .350 | 10.5 | 151 | 169 | .449 |
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