MLB Scores and Standings Wednesday, April 21, 2021
| San Francisco Giants | 5 | Final |
| Philadelphia Phillies | 6 |
| W | Héctor Neris (1-1) |
| L | Wandy Peralta (2-1) |
| Baltimore Orioles | 0 | Final |
| Miami Marlins | 3 |
| W | Trevor Rogers (2-1) |
| L | Bruce Zimmermann (1-2) |
| S | Yimi García (4) |
| Pittsburgh Pirates | 3 | Final |
| Detroit Tigers | 2 | (7) |
| W | Tyler Anderson (2-2) |
| L | Michael Fulmer (1-1) |
| S | Richard Rodríguez (2) |
| Houston Astros | 3 | Final |
| Colorado Rockies | 6 |
| W | Austin Gomber (1-2) |
| L | José Urquidy (0-2) |
| Minnesota Twins | 12 | Final |
| Oakland Athletics | 13 | (10) |
| W | Deolis Guerra (1-0) |
| L | Alex Colomé (1-2) |
| St. Louis Cardinals | 0 | Final |
| Washington Nationals | 1 |
| W | Max Scherzer (1-1) |
| L | Carlos Martínez (0-4) |
| S | Brad Hand (3) |
| Texas Rangers | 7 | Final |
| Los Angeles Angels | 4 |
| W | John King (2-0) |
| L | Mike Mayers (1-1) |
| Milwaukee Brewers | 4 | Final |
| San Diego Padres | 2 |
| W | Brent Suter (1-1) |
| L | Keone Kela (2-1) |
| S | Josh Hader (3) |
| Atlanta Braves | 4 | Final |
| New York Yankees | 1 |
| W | Ian Anderson (1-0) |
| L | Corey Kluber (0-2) |
| Pittsburgh Pirates | 2 | Final |
| Detroit Tigers | 5 | (7) |
| W | Spencer Turnbull (1-0) |
| L | Miguel Yajure (0-1) |
| S | Gregory Soto (2) |
| Arizona Diamondbacks | 8 | Final |
| Cincinnati Reds | 5 | (10) |
| W | Taylor Clarke (1-0) |
| L | Cionel Pérez (1-2) |
| Toronto Blue Jays | 6 | Final |
| Boston Red Sox | 3 |
| W | Ryan Borucki (2-1) |
| L | Garrett Richards (0-2) |
| S | Anthony Castro (1) |
| New York Mets | 4 | Final |
| Chicago Cubs | 16 |
| W | Alec Mills (1-0) |
| L | David Peterson (1-2) |
| Tampa Bay Rays | 8 | Final |
| Kansas City Royals | 9 |
| W | Scott Barlow (1-0) |
| L | Diego Castillo (0-1) |
Standings Up to and Including this Date
AL East Division
AL Central Division
AL West Division
NL East Division
NL Central Division
AL Overall
| Tm | W | L | GB | RS | RA | pythW-L% | |
|---|---|---|---|---|---|---|---|
| OAK | 12 | 7 | .632 | -- | 90 | 92 | .490 |
| BOS | 12 | 7 | .632 | -- | 103 | 76 | .636 |
| SEA | 11 | 7 | .611 | 0.5 | 74 | 77 | .482 |
| KCR | 10 | 7 | .588 | 1.0 | 79 | 85 | .467 |
| LAA | 9 | 7 | .563 | 1.5 | 85 | 83 | .511 |
| TBR | 10 | 9 | .526 | 2.0 | 94 | 98 | .481 |
| CHW | 9 | 9 | .500 | 2.5 | 89 | 75 | .578 |
| CLE | 8 | 8 | .500 | 2.5 | 62 | 60 | .515 |
| TEX | 9 | 10 | .474 | 3.0 | 74 | 85 | .437 |
| TOR | 8 | 10 | .444 | 3.5 | 74 | 64 | .566 |
| BAL | 8 | 10 | .444 | 3.5 | 71 | 77 | .463 |
| HOU | 7 | 10 | .412 | 4.0 | 77 | 78 | .494 |
| DET | 7 | 11 | .389 | 4.5 | 62 | 88 | .345 |
| MIN | 6 | 11 | .353 | 5.0 | 79 | 82 | .483 |
| NYY | 6 | 11 | .353 | 5.0 | 59 | 69 | .429 |
NL Overall
| Tm | W | L | GB | RS | RA | pythW-L% | |
|---|---|---|---|---|---|---|---|
| LAD | 14 | 4 | .778 | -- | 94 | 56 | .721 |
| MIL | 11 | 7 | .611 | 3.0 | 79 | 55 | .660 |
| SFG | 11 | 7 | .611 | 3.0 | 66 | 59 | .551 |
| NYM | 8 | 6 | .571 | 4.0 | 48 | 61 | .392 |
| CIN | 9 | 8 | .529 | 4.5 | 100 | 80 | .601 |
| PHI | 9 | 9 | .500 | 5.0 | 70 | 76 | .462 |
| SDP | 10 | 10 | .500 | 5.0 | 72 | 69 | .519 |
| CHC | 8 | 9 | .471 | 5.5 | 70 | 79 | .445 |
| STL | 8 | 10 | .444 | 6.0 | 85 | 87 | .489 |
| MIA | 8 | 10 | .444 | 6.0 | 79 | 76 | .518 |
| PIT | 8 | 10 | .444 | 6.0 | 70 | 88 | .397 |
| ARI | 8 | 10 | .444 | 6.0 | 86 | 92 | .469 |
| ATL | 8 | 10 | .444 | 6.0 | 86 | 87 | .495 |
| WSN | 7 | 9 | .438 | 6.0 | 55 | 75 | .362 |
| COL | 6 | 12 | .333 | 8.0 | 78 | 81 | .483 |
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