MLB Scores and Standings Friday, May 22, 1981
| San Diego Padres | 5 | Final |
| Atlanta Braves | 2 |
| W | Juan Eichelberger (4-2) |
| L | Tommy Boggs (1-7) |
| S | Gary Lucas (7) |
| Chicago White Sox | 9 | Final |
| California Angels | 5 |
| W | Britt Burns (4-2) |
| L | Ken Forsch (6-2) |
| S | Ed Farmer (5) |
| Montreal Expos | 6 | Final |
| Chicago Cubs | 3 |
| W | Charlie Lea (3-1) |
| L | Mike Krukow (1-5) |
| Los Angeles Dodgers | 4 | Final |
| Cincinnati Reds | 2 | (12) |
| W | Dave Stewart (2-0) |
| L | Doug Bair (1-1) |
| Baltimore Orioles | 4 | Final |
| Detroit Tigers | 2 |
| W | Scott McGregor (5-1) |
| L | Milt Wilcox (5-4) |
| S | Tippy Martinez (7) |
| San Francisco Giants | 6 | Final |
| Houston Astros | 3 | (15) |
| W | Greg Minton (2-2) |
| L | Joaquín Andújar (1-3) |
| Minnesota Twins | 7 | Final |
| Kansas City Royals | 0 |
| W | Jerry Koosman (2-6) |
| L | Dennis Leonard (4-5) |
| Boston Red Sox | 7 | Final |
| Milwaukee Brewers | 3 |
| W | John Tudor (2-1) |
| L | Moose Haas (3-3) |
| Cleveland Indians | 7 | Final |
| New York Yankees | 3 |
| W | Bert Blyleven (6-1) |
| L | Tommy John (5-4) |
| Toronto Blue Jays | 2 | Final |
| Oakland Athletics | 6 |
| W | Rick Langford (5-4) |
| L | Dave Stieb (3-5) |
| Philadelphia Phillies | 1 | Final |
| Pittsburgh Pirates | 3 |
| W | Pascual Pérez (1-0) |
| L | Larry Christenson (1-4) |
| Texas Rangers | 6 | Final |
| Seattle Mariners | 2 |
| W | Danny Darwin (5-3) |
| L | Floyd Bannister (4-4) |
| New York Mets | 9 | Final |
| St. Louis Cardinals | 3 |
| W | Pat Zachry (4-5) |
| L | Silvio Martínez (1-3) |
Standings Up to and Including this Date
AL East Division
AL West Division
NL East Division
AL Overall
| Tm | W | L | GB | RS | RA | pythW-L% | |
|---|---|---|---|---|---|---|---|
| BAL | 23 | 12 | .657 | -- | 156 | 120 | .618 |
| OAK | 26 | 16 | .619 | 0.5 | 180 | 134 | .632 |
| CLE | 20 | 12 | .625 | 1.5 | 111 | 100 | .548 |
| NYY | 22 | 15 | .595 | 2.0 | 142 | 121 | .573 |
| CHW | 20 | 15 | .571 | 3.0 | 168 | 137 | .592 |
| BOS | 21 | 16 | .568 | 3.0 | 173 | 178 | .487 |
| TEX | 20 | 16 | .556 | 3.5 | 177 | 156 | .558 |
| MIL | 20 | 16 | .556 | 3.5 | 163 | 142 | .563 |
| CAL | 21 | 21 | .500 | 5.5 | 183 | 169 | .536 |
| DET | 18 | 19 | .486 | 6.0 | 138 | 150 | .462 |
| SEA | 13 | 25 | .342 | 11.5 | 138 | 195 | .347 |
| MIN | 12 | 25 | .324 | 12.0 | 135 | 169 | .399 |
| KCR | 9 | 22 | .290 | 12.0 | 91 | 143 | .304 |
| TOR | 12 | 27 | .308 | 13.0 | 128 | 169 | .376 |
NL Overall
| Tm | W | L | GB | RS | RA | pythW-L% | |
|---|---|---|---|---|---|---|---|
| LAD | 28 | 11 | .718 | -- | 152 | 97 | .695 |
| STL | 21 | 11 | .656 | 3.5 | 165 | 137 | .584 |
| PHI | 23 | 15 | .605 | 4.5 | 162 | 142 | .560 |
| CIN | 22 | 16 | .579 | 5.5 | 166 | 145 | .562 |
| MON | 21 | 16 | .568 | 6.0 | 152 | 153 | .497 |
| SFG | 22 | 20 | .524 | 7.5 | 150 | 142 | .525 |
| ATL | 18 | 19 | .486 | 9.0 | 146 | 144 | .506 |
| PIT | 15 | 16 | .484 | 9.0 | 123 | 109 | .555 |
| HOU | 19 | 21 | .475 | 9.5 | 137 | 125 | .542 |
| SDP | 16 | 24 | .400 | 12.5 | 135 | 167 | .404 |
| NYM | 10 | 24 | .294 | 15.5 | 109 | 162 | .326 |
| CHC | 6 | 28 | .176 | 19.5 | 95 | 169 | .258 |
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