MLB Scores and Standings Wednesday, April 22, 1981
| Texas Rangers | 16 | Final |
| Boston Red Sox | 8 |
| W | Danny Darwin (1-2) |
| L | Dennis Eckersley (1-1) |
| Seattle Mariners | 3 | Final |
| California Angels | 7 |
| W | Ken Forsch (2-0) |
| L | Ken Clay (0-2) |
| Atlanta Braves | 7 | Final |
| Cincinnati Reds | 3 |
| W | Gaylord Perry (1-1) |
| L | Mike LaCoss (0-2) |
| Los Angeles Dodgers | 1 | Final |
| Houston Astros | 0 |
| W | Fernando Valenzuela (4-0) |
| L | Don Sutton (0-3) |
| Cleveland Indians | 4 | Final |
| Kansas City Royals | 0 |
| W | Len Barker (1-1) |
| L | Dennis Leonard (1-2) |
| Philadelphia Phillies | 3 | Final |
| Montreal Expos | 4 | (11) |
| W | Elías Sosa (1-0) |
| L | Tug McGraw (1-2) |
| Detroit Tigers | 2 | Final |
| New York Yankees | 7 |
| W | Dave LaRoche (1-0) |
| L | Howard Bailey (1-2) |
| Minnesota Twins | 1 | Final |
| Oakland Athletics | 2 |
| W | Brian Kingman (2-0) |
| L | Albert Williams (0-3) |
| S | Jeff Jones (1) |
| San Francisco Giants | 0 | Final |
| San Diego Padres | 4 |
| W | Juan Eichelberger (1-1) |
| L | Ed Whitson (0-2) |
| S | Gary Lucas (2) |
| Chicago Cubs | 0 | Final |
| St. Louis Cardinals | 3 |
| W | Lary Sorensen (3-0) |
| L | Mike Krukow (0-1) |
| Milwaukee Brewers | 8 | Final |
| Toronto Blue Jays | 1 |
| W | Mike Caldwell (2-1) |
| L | Luis Leal (1-2) |
Standings Up to and Including this Date
AL East Division
AL West Division
NL East Division
AL Overall
| Tm | W | L | GB | RS | RA | pythW-L% | |
|---|---|---|---|---|---|---|---|
| OAK | 14 | 1 | .933 | -- | 74 | 21 | .909 |
| CLE | 6 | 3 | .667 | 5.0 | 29 | 23 | .604 |
| NYY | 7 | 4 | .636 | 5.0 | 47 | 33 | .656 |
| CHW | 5 | 3 | .625 | 5.5 | 36 | 34 | .526 |
| BOS | 6 | 4 | .600 | 5.5 | 56 | 49 | .561 |
| DET | 7 | 5 | .583 | 5.5 | 43 | 47 | .459 |
| MIL | 5 | 4 | .556 | 6.0 | 37 | 31 | .580 |
| CAL | 6 | 7 | .462 | 7.0 | 52 | 53 | .491 |
| TEX | 5 | 6 | .455 | 7.0 | 52 | 54 | .483 |
| BAL | 3 | 4 | .429 | 7.0 | 20 | 22 | .457 |
| SEA | 4 | 9 | .308 | 9.0 | 44 | 78 | .260 |
| KCR | 2 | 7 | .222 | 9.0 | 20 | 34 | .275 |
| TOR | 3 | 9 | .250 | 9.5 | 42 | 55 | .379 |
| MIN | 2 | 9 | .182 | 10.0 | 24 | 42 | .264 |
NL Overall
| Tm | W | L | GB | RS | RA | pythW-L% | |
|---|---|---|---|---|---|---|---|
| LAD | 10 | 2 | .833 | -- | 43 | 19 | .817 |
| MON | 8 | 2 | .800 | 1.0 | 54 | 39 | .645 |
| STL | 7 | 2 | .778 | 1.5 | 53 | 24 | .810 |
| PHI | 7 | 5 | .583 | 3.0 | 55 | 50 | .543 |
| ATL | 6 | 5 | .545 | 3.5 | 38 | 36 | .525 |
| NYM | 4 | 4 | .500 | 4.0 | 26 | 25 | .518 |
| PIT | 4 | 4 | .500 | 4.0 | 29 | 30 | .484 |
| CIN | 5 | 6 | .455 | 4.5 | 45 | 50 | .452 |
| SDP | 5 | 8 | .385 | 5.5 | 27 | 53 | .225 |
| SFG | 5 | 8 | .385 | 5.5 | 41 | 43 | .478 |
| HOU | 3 | 9 | .250 | 7.0 | 26 | 34 | .380 |
| CHC | 1 | 10 | .091 | 8.5 | 17 | 51 | .118 |
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